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Mouse Anti-PPM1K Recombinant Antibody (E-3) (CBMAB-P2569-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Phosphatase, Mg2+/Mn2+ Dependent 1K. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PPM1K antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
E-3
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Phosphatase, Mg2+/Mn2+ Dependent 1K
Introduction
PPM1K is a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore.
Entrez Gene ID
Human152926
Mouse243382
Rat312381
UniProt ID
HumanQ8N3J5
MouseQ8BXN7
RatD4A7X5
Alternative Names
BDP; MSUDMV; PP2Ckappa; PP2Cm; PTMP; UG0882E07
Function
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
Biological Process
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion matrix
Involvement in disease
Maple syrup urine disease, mild variant (MSUDMV):
A mild form of maple syrup urine disease, a metabolic disorder due to an enzyme defect in the catabolic pathway of the branched-chain amino acids leucine, isoleucine, and valine. Accumulation of these 3 amino acids and their corresponding keto acids leads to encephalopathy and progressive neurodegeneration. Clinical features include mental and physical retardation, feeding problems, and a maple syrup odor to the urine. The keto acids of the branched-chain amino acids are present in the urine. If untreated, maple syrup urine disease can lead to seizures, coma, and death. The disease is often classified by its pattern of signs and symptoms. The most common and severe form of the disease is the classic type, which becomes apparent soon after birth. Variant forms of the disorder become apparent later in infancy or childhood and are typically milder, but they still involve developmental delay and other medical problems if not treated. MSUDMV is characterized by increased plasma levels of branched-chain amino acids (BCAA) apparent at birth. Treatment with a low-protein diet free of BCAA can result in normal psychomotor development and lack of metabolic episodes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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