Sign in or Register   Sign in or Register
  |  

Mouse Anti-PRUNE1 Recombinant Antibody (6D711) (CBMAB-P3092-YC)

Provided herein is a Mouse monoclonal antibody against Human Prune Exopolyphosphatase 1. The antibody can be used for immunoassay techniques, such as ICC, IHC, WB.
See all PRUNE1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6D711
Antibody Isotype
IgM
Application
ICC, IHC, WB

Basic Information

Immunogen
Recombinant human PRUNE
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Prune Exopolyphosphatase 1
Introduction
PRUNE1 is a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility.
Entrez Gene ID
58497
UniProt ID
Q86TP1
Alternative Names
DRES17; HTCD37; DRES-17
Function
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956).
Involved in the regulation of microtubule polymerization (PubMed:28334956).
Biological Process
Regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of neurogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cell junction, focal adhesion
In some transfected cells a nuclear staining is also observed.
Involvement in disease
Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA):
An autosomal recessive neurodevelopmental and degenerative disorder characterized by primary microcephaly, profound global developmental delay, and severe intellectual disability. Additional clinical features include dysmorphic features, truncal hypotonia, peripheral spasticity, and lack of independent ambulation or speech acquisition. Brain imaging shows cortical atrophy, thin corpus callosum, cerebellar hypoplasia, and delayed myelination.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PRUNE1 Recombinant Antibody (6D711)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare