Mouse Anti-PRUNE1 Recombinant Antibody (6D711) (CBMAB-P3092-YC)

Name: Mouse Anti-PRUNE1 Recombinant Antibody (6D711)
SKU: CBMAB-P3092-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6D711

Application

ICC, IHC, WB

Immunogen

Recombinant human PRUNE

Specificity

Human

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Prune Exopolyphosphatase 1

Introduction

PRUNE1 is a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility.

Entrez Gene ID

58497

UniProt ID

Q86TP1

Alternative Names

DRES17; HTCD37; DRES-17

Function

Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956).
Involved in the regulation of microtubule polymerization (PubMed:28334956).

Biological Process

Regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of neurogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cell junction, focal adhesion
In some transfected cells a nuclear staining is also observed.

Involvement in disease

Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA):
An autosomal recessive neurodevelopmental and degenerative disorder characterized by primary microcephaly, profound global developmental delay, and severe intellectual disability. Additional clinical features include dysmorphic features, truncal hypotonia, peripheral spasticity, and lack of independent ambulation or speech acquisition. Brain imaging shows cortical atrophy, thin corpus callosum, cerebellar hypoplasia, and delayed myelination.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-PRUNE1 Recombinant Antibody (1C11) (CAT#: CBMAB-P3091-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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