Mouse Anti-PTCH2 Recombinant Antibody (1F5) (CBMAB-P3295-YC)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).
Epidermal cell fate specificationIEA:Ensembl
Hair cycleIEA:Ensembl
Negative regulation of smoothened signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of epidermal cell differentiationIEA:Ensembl
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Skin developmentIEA:Ensembl
Smoothened signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Basal cell carcinoma (BCC):
A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. BCC is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.
Basal cell nevus syndrome (BCNS):
An autosomal dominant disease characterized by nevoid basal cell carcinomas and developmental abnormalities such as rib and craniofacial alterations, polydactyly, syndactyly, and spina bifida. In addition, the patients suffer from a multitude of tumors like basal cell carcinomas, fibromas of the ovaries and heart, cysts of the skin, jaws and mesentery, as well as medulloblastomas and meningiomas.
Helical: 58-78
Extracellular: 79-392
Helical: 393-413
Cytoplasmic: 414-428
Helical: 429-449
Extracellular: 450-457
Helical: 458-478
Cytoplasmic: 479-501
Helical: 502-522
Extracellular: 523-531
Helical: 532-552
Cytoplasmic: 553-686
Helical: 687-707
Extracellular: 708-963
Helical: 964-984
Cytoplasmic: 985-991
Helical: 992-1012
Extracellular: 1013
Helical: 1014-1034
Cytoplasmic: 1035-1064
Helical: 1065-1085
Extracellular: 1086-1093
Helical: 1094-1114
Cytoplasmic: 1115-1203
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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