Sign in or Register   Sign in or Register
  |  

Mouse Anti-PTCH2 Recombinant Antibody (1F5) (CBMAB-P3295-YC)

Provided herein is a Mouse monoclonal antibody against Human Patched 2. The antibody can be used for immunoassay techniques, such as WB.
See all PTCH2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F5
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 79-392 of human PTCH2 (NP_003729) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Patched 2
Introduction
PTCH2 is a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia.
Entrez Gene ID
8643
UniProt ID
Q9Y6C5
Alternative Names
PTC2
Function
Plays a role in the control of cellular growth (PubMed:18285427).
May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).
Biological Process
Cell fate determinationIEA:Ensembl
Epidermal cell fate specificationIEA:Ensembl
Hair cycleIEA:Ensembl
Negative regulation of smoothened signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of epidermal cell differentiationIEA:Ensembl
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Skin developmentIEA:Ensembl
Smoothened signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Involvement in disease
Medulloblastoma (MDB):
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Basal cell carcinoma (BCC):
A common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. BCC is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.
Basal cell nevus syndrome (BCNS):
An autosomal dominant disease characterized by nevoid basal cell carcinomas and developmental abnormalities such as rib and craniofacial alterations, polydactyly, syndactyly, and spina bifida. In addition, the patients suffer from a multitude of tumors like basal cell carcinomas, fibromas of the ovaries and heart, cysts of the skin, jaws and mesentery, as well as medulloblastomas and meningiomas.
Topology
Cytoplasmic: 1-57
Helical: 58-78
Extracellular: 79-392
Helical: 393-413
Cytoplasmic: 414-428
Helical: 429-449
Extracellular: 450-457
Helical: 458-478
Cytoplasmic: 479-501
Helical: 502-522
Extracellular: 523-531
Helical: 532-552
Cytoplasmic: 553-686
Helical: 687-707
Extracellular: 708-963
Helical: 964-984
Cytoplasmic: 985-991
Helical: 992-1012
Extracellular: 1013
Helical: 1014-1034
Cytoplasmic: 1035-1064
Helical: 1065-1085
Extracellular: 1086-1093
Helical: 1094-1114
Cytoplasmic: 1115-1203
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PTCH2 Recombinant Antibody (1F5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare