Mouse Anti-RBP3 Recombinant Antibody (CBCNR-328) (CBMAB-R1797-CN)

Name: Mouse Anti-RBP3 Recombinant Antibody (CBCNR-328)
SKU: CBMAB-R1797-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNR-328

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Retinol Binding Protein 3, Interstitial

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

retinol binding protein 3, interstitial

Introduction

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]

Entrez Gene ID

5949

UniProt ID

P10745

Alternative Names

Retinol Binding Protein 3; Interphotoreceptor Retinoid-Binding Protein; IRBP; Retinol-Binding Protein 3, Interstitial; Retinol Binding Protein 3, Interstitial; Interstitial Retinol-Binding Protein 3; Interstitial Retinol Binding Protein 3; Interstitial Retinol-Binding Protein;

Function

IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.

Biological Process

Biological Process lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process proteolysisIEA:InterPro
Biological Process retinoid metabolic processTAS:Reactome
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix
Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.

Involvement in disease

Retinitis pigmentosa 66 (RP66):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-RBP3 Recombinant Antibody (CBCNR-327) (CAT#: CBMAB-R1796-CN)

Mouse Anti-RBP3 Recombinant Antibody (4F3) (CAT#: CBMAB-R1795-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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