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Mouse Anti-RDH12 Recombinant Antibody (1E11) (CBMAB-R1983-CN)

This product is a Mouse antibody that recognizes RDH12. The antibody 1E11 can be used for immunoassay techniques such as: ELISA, WB.
See all RDH12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa. 217-317 from human RDH12 (NP_689656) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Introduction
The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 13 and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]
Entrez Gene ID
145226
UniProt ID
Q96NR8
Alternative Names
Retinol Dehydrogenase 12 (All-Trans/9-Cis/11-Cis); Short Chain Dehydrogenase/Reductase Family 7C Member 2; All-Trans And 9-Cis Retinol Dehydrogenase; SDR7C2; Short Chain Dehydrogenase/Reductase Family 7C, Member 2; Retinol Dehydrogenase 12 (All-Trans And 9-Cis); Retinol Dehydrogenase 12, All-Trans And 9-Cis;
Function
Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol (PubMed:15865448, PubMed:12226107).
Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (PubMed:19686838, PubMed:15865448).
May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation (PubMed:19686838).
Has no dehydrogenase activity towards steroids (PubMed:15865448, PubMed:12226107).
Biological Process
Biological Process cellular detoxification of aldehydeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process photoreceptor cell maintenanceManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process retinoid metabolic processTAS:Reactome
Biological Process retinol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process visual perceptionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Leber congenital amaurosis 13 (LCA13):
A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
Retinitis pigmentosa 53 (RP53):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP53 inheritance is autosomal dominant or autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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