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Mouse Anti-RNF170 Recombinant Antibody (2D6) (CBMAB-R2965-CN)

This product is a Mouse antibody that recognizes RNF170. The antibody 2D6 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF170 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D6
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 121-194 from human RNF170 (NP_112216) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ring finger protein 170
Introduction
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Entrez Gene ID
81790
UniProt ID
Q96K19
Alternative Names
Ring Finger Protein 170; RING-Type E3 Ubiquitin Transferase RNF170; Putative LAG1-Interacting Protein; RING Finger Protein 170; Sensory Ataxia 1 (Autosomal Dominant); E3 Ubiquitin-Protein Ligase RNF170; EC 2.3.2.27; SNAX1; ADSA;
Function
E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Ataxia, sensory, 1, autosomal dominant (SNAX1):
A rare disease characterized by progressive ataxia caused by degeneration of the posterior columns of the spinal cord. Affected individuals have a reduced ability to feel pain, temperature and vibration, particularly in the hands and feet. Their most prominent feature is an ataxic gait resulting from a severe loss of proprioception. Thus, patients rely on visual cues for maintaining proper body posture, such that they are unable to remain upright if their eyes are closed (Romberg sign).
Topology
Lumenal: 1-24
Helical: 25-45
Cytoplasmic: 46-201
Helical: 202-222
Lumenal: 223
Helical: 224-244
Cytoplasmic: 245-258
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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