Mouse Anti-RNF170 Recombinant Antibody (2D6) (CBMAB-R2965-CN)

Name: Mouse Anti-RNF170 Recombinant Antibody (2D6)
SKU: CBMAB-R2965-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2D6

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa. 121-194 from human RNF170 (NP_112216) with GST tag

Specificity

Human

Antibody Isotype

IgG2b, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

More Infomation

Target

Full Name

ring finger protein 170

Introduction

This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Entrez Gene ID

81790

UniProt ID

Q96K19

Alternative Names

Ring Finger Protein 170; RING-Type E3 Ubiquitin Transferase RNF170; Putative LAG1-Interacting Protein; RING Finger Protein 170; Sensory Ataxia 1 (Autosomal Dominant); E3 Ubiquitin-Protein Ligase RNF170; EC 2.3.2.27; SNAX1; ADSA;

Function

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Ataxia, sensory, 1, autosomal dominant (SNAX1):
A rare disease characterized by progressive ataxia caused by degeneration of the posterior columns of the spinal cord. Affected individuals have a reduced ability to feel pain, temperature and vibration, particularly in the hands and feet. Their most prominent feature is an ataxic gait resulting from a severe loss of proprioception. Thus, patients rely on visual cues for maintaining proper body posture, such that they are unable to remain upright if their eyes are closed (Romberg sign).

Topology

Lumenal: 1-24
Helical: 25-45
Cytoplasmic: 46-201
Helical: 202-222
Lumenal: 223
Helical: 224-244
Cytoplasmic: 245-258

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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