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Mouse Anti-SLC26A3 Recombinant Antibody (CBXS-4536) (CBMAB-S1776-CQ)

This product is a mouse antibody that recognizes SLC26A3. The antibody CBXS-4536 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC26A3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4536
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 26, member 3
Introduction
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.
Entrez Gene ID
1811
UniProt ID
P40879
Alternative Names
Solute Carrier Family 26 Member 3; Solute Carrier Family 26 (Anion Exchanger), Member 3; DRA; Solute Carrier Family 26, Member 3; Down-Regulated In Adenoma Protein; Congenital Chloride Diarrhea;
Function
Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Biological Process
Biological Process anion transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to cAMPISS:UniProtKB
Biological Process intracellular pH elevationISS:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process membrane hyperpolarizationISS:UniProtKB
Biological Process sperm capacitationISS:UniProtKB
Cellular Location
Apical cell membrane
Membrane
Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity).
Involvement in disease
Diarrhea 1, secretory chloride, congenital (DIAR1):
A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
PTM
N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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