Mouse Anti-SLC26A3 Recombinant Antibody (CBXS-4536) (CBMAB-S1776-CQ)

Name: Mouse Anti-SLC26A3 Recombinant Antibody (CBXS-4536)
SKU: CBMAB-S1776-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4536

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 26, member 3

Introduction

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea.

Entrez Gene ID

1811

UniProt ID

P40879

Alternative Names

Solute Carrier Family 26 Member 3; Solute Carrier Family 26 (Anion Exchanger), Member 3; DRA; Solute Carrier Family 26, Member 3; Down-Regulated In Adenoma Protein; Congenital Chloride Diarrhea;

Function

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

Biological Process

Biological Process anion transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to cAMPISS:UniProtKB
Biological Process intracellular pH elevationISS:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process membrane hyperpolarizationISS:UniProtKB
Biological Process sperm capacitationISS:UniProtKB

Cellular Location

Apical cell membrane
Membrane
Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity).

Involvement in disease

Diarrhea 1, secretory chloride, congenital (DIAR1):
A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.

PTM

N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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