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Mouse Anti-SLC26A4 Recombinant Antibody (CBXS-5559) (CBMAB-S2766-CQ)

This product is a mouse antibody that recognizes SLC26A4. The antibody CBXS-5559 can be used for immunoassay techniques such as: IHC.
See all SLC26A4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5559
Antibody Isotype
IgG1
Application
IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 26, member 4
Introduction
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters.
Entrez Gene ID
5172
UniProt ID
O43511
Alternative Names
Solute Carrier Family 26 Member 4; Solute Carrier Family 26 (Anion Exchanger), Member 4; Sodium-Independent Chloride/Iodide Transporter; Pendrin; PDS; Solute Carrier Family 26, Member 4;
Function
Sodium-independent transporter of chloride and iodide.
Biological Process
Biological Process inorganic anion transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process ion transportTAS:Reactome
Biological Process regulation of pHISS:UniProtKB
Biological Process regulation of protein localizationISS:UniProtKB
Biological Process sensory perception of soundManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sulfate transportManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Cell membrane
Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.
Involvement in disease
Pendred syndrome (PDS):
An autosomal recessive disorder characterized by congenital sensorineural hearing loss in association with thyroid goiter. The disorder may account for up to 10% of the cases of hereditary deafness. The deafness is most often associated with a Mondini cochlear defect. Deafness occurs early, starting at birth or during the first years of life. It is bilateral, sometimes asymmetrical, fluctuant and often progressive. Thyroid perturbations, such as thyroid goiter and/or hypothyroidism appear most commonly during adolescence, but they can be congenital or appear later.
Deafness, autosomal recessive, 4 (DFNB4):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB4 is associated with an enlarged vestibular aqueduct.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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