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Mouse Anti-SLC5A7 Recombinant Antibody (5K101) (CBMAB-C1369-YY)

This product is mouse antibody that recognizes SLC5A7. The antibody 5K101 can be used for immunoassay techniques such as: IP, FC
See all SLC5A7 antibodies

Summary

Host Animal
Mouse
Specificity
Avian, Chicken
Clone
5K101
Application
IP, FC

Basic Information

Specificity
Avian, Chicken
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
100 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 5 Member 7
Entrez Gene ID
414870
UniProt ID
F1P4Q0
Alternative Names
Cyclin D3;
Function
Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent.
Biological Process
Biological Process acetylcholine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process choline transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process neuromuscular synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter transportTAS:Reactome
Biological Process synaptic transmission, cholinergicManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transmembrane transportTAS:Reactome
Cellular Location
Membrane
Cell membrane
Synapse
Localized at the neuromuscular junction.
Involvement in disease
Neuronopathy, distal hereditary motor, 7A (HMN7A):
A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. HMN7A is characterized by onset in the second decade of progressive distal muscle wasting and weakness affecting the upper and lower limbs and resulting in walking difficulties and hand grip. There is significant muscle atrophy of the hands and lower limbs. The disorder is associated with vocal cord paresis due to involvement of the tenth cranial nerve.
Myasthenic syndrome, congenital, 20, presynaptic (CMS20):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS20 is an autosomal recessive, pre-synaptic form characterized by severe hypotonia and episodic apnea soon after birth, generalized limb fatigability and weakness, delayed walking, ptosis, poor sucking and swallowing.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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