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Mouse Anti-SMAD1 Monoclonal Antibody (1B12) (CBMAB-0113-LY)

This product is mouse monoclonal antibody recognizes SMAD1 of human. The antibody 1B12 immunoassay techniques such as: IP, MA, WB.
Host Species
Mouse
Application
IP, MA, WB
Immunogen
Recombinant peptide (Full Length)
Antibody Isotype
IgG2b
Specificity
Human
Clone
1B12
Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Alternative Name
JV4-1; MADH1; MADR1
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0113-LY
Conjugates
Size
Price $
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Second antibody and isotype control