Sign in or Register   Sign in or Register
  |  

Mouse Anti-STX1B Recombinant Antibody (CBXS-4490) (CBMAB-S1732-CQ)

This product is a mouse antibody that recognizes STX1B. The antibody CBXS-4490 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all STX1B antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-4490
Antibody Isotype
IgG1
Application
ELISA, IHC, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Syntaxin 1B
Introduction
The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested.
Entrez Gene ID
Human112755
Mouse56216
Rat24923
UniProt ID
HumanP61266
MouseP61264
RatP61265
Alternative Names
GEFSP9; STX1B1; STX1B2
Function
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm (By similarity).
Biological Process
Biological Process calcium ion-regulated exocytosis of neurotransmitterIEA:Ensembl
Biological Process exocytic insertion of neurotransmitter receptor to postsynaptic membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of macropinocytosisISS:ParkinsonsUK-UCL
Biological Process negative regulation of neuron projection developmentISS:ParkinsonsUK-UCL
Biological Process negative regulation of synaptic vesicle recyclingIEA:Ensembl
Biological Process positive regulation of excitatory postsynaptic potentialISS:ParkinsonsUK-UCL
Biological Process positive regulation of neurotransmitter secretionISS:ParkinsonsUK-UCL
Biological Process positive regulation of spontaneous neurotransmitter secretionIEA:Ensembl
Biological Process regulation of exocytosisIEA:InterPro
Biological Process regulation of gene expressionISS:ParkinsonsUK-UCL
Biological Process regulation of synaptic activityISS:ParkinsonsUK-UCL
Biological Process regulation of synaptic vesicle primingISS:ParkinsonsUK-UCL
Biological Process spontaneous neurotransmitter secretionIEA:Ensembl
Biological Process synaptic vesicle dockingISS:ParkinsonsUK-UCL
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle dockingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle docking involved in exocytosisISS:ParkinsonsUK-UCL
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Membrane
Isoform 2
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.
Involvement in disease
Generalized epilepsy with febrile seizures plus 9 (GEFSP9):
An autosomal dominant neurologic disorder characterized by febrile and/or afebrile seizures manifesting in early childhood. Seizure are variable and include generalized tonic-clonic, atonic, myoclonic, complex partial, and absence types. Most patients have remission of seizures later in childhood with no residual neurologic deficits. Rarely, patients may show mild developmental delay or mild intellectual disabilities.
Topology
Cytoplasmic: 1-264
Helical: 265-288
PTM
Phosphorylated by CK2.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-STX1B Recombinant Antibody (CBXS-4490)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare