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Rabbit Anti-SUCLA2 Recombinant Antibody (CBXS-1392) (CBMAB-S4250-CQ)

This product is a rabbit antibody that recognizes SUCLA2. The antibody CBXS-1392 can be used for immunoassay techniques such as: WB, IHC-P, FC, IF.
See all SUCLA2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1392
Antibody Isotype
IgG
Application
WB, IHC-P, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Succinate-CoA Ligase ADP-Forming Beta Subunit
Introduction
Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.
Entrez Gene ID
Human8803
Mouse20916
Rat361071
UniProt ID
HumanQ9P2R7
MouseQ9Z2I9
RatF1LM47
Alternative Names
A-BETA; A-SCS; MTDPS5; SCS-betaA
Function
ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282).
The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity).
Biological Process
Biological Process succinate metabolic processIEA:Ensembl
Biological Process succinyl-CoA catabolic process1 PublicationIC:ComplexPortal
Biological Process succinyl-CoA metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process succinyl-CoA pathway1 PublicationNAS:UniProtKB
Biological Process tricarboxylic acid cycleManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrial DNA depletion syndrome 5 (MTDPS5):
A disorder due to mitochondrial dysfunction. It is characterized by infantile onset of hypotonia, neurologic deterioration, a hyperkinetic-dystonic movement disorder, external ophthalmoplegia, deafness, variable renal tubular dysfunction, and mild methylmalonic aciduria in some patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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