Mouse Anti-TBC1D7 Recombinant Antibody (CBYJT-2055) (CBMAB-T1151-YJ)

Name: Mouse Anti-TBC1D7 Recombinant Antibody (CBYJT-2055)
SKU: CBMAB-T1151-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-2055

Application

WB, IP, IF, ELISA

Immunogen

Specific for an epitope mapping between amino acids 1-16 at the N-terminus of TBC1D7 of human origin

Specificity

Human, Rat, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-16

More Infomation

Target

Full Name

TBC1D7 Gene(Protein Coding) TBC1 Domain Family Member 7

Introduction

TBC1D7 is a member of the TBC-domain containing protein family. TBC1D7 plays a role as a subunit of the tuberous sclerosis TSC1-TSC2 complex which plays a role in the regulation of cellular growth and differentiation. Mutations in TBC1D7 have been associated with autosomal recessive megalencephaly.

Entrez Gene ID

Human	51256
Mouse	67046
Rat	361227

UniProt ID

Human	Q9P0N9
Mouse	Q9D0K0
Rat	D4AAY4

Alternative Names

TBC1 Domain Family Member 7; Cell Migration-Inducing Protein 23; TS Complex Subunit 3; TBC7; TBC1 Domain Family, Member 7; MGCPH; PIG51

Function

Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.

Biological Process

Biological Process activation of GTPase activityIMP:UniProtKB1 Publication
Biological Process negative regulation of cilium assemblyIMP:UniProtKB1 Publication
Biological Process negative regulation of TOR signalingIDA:ComplexPortal1 Publication
Biological Process positive regulation of GTPase activityIDA:UniProtKB1 Publication
Biological Process positive regulation of protein ubiquitinationIDA:UniProtKB1 Publication
Biological Process response to growth factorIMP:UniProtKB1 Publication

Cellular Location

Cytoplasmic vesicle
Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.

Involvement in disease

Macrocephaly/megalencephaly syndrome, autosomal recessive (MGCPH):
An autosomal recessive disorder characterized by abnormal enlargement of the cerebral hemispheres, intellectual disability, large head, optic atrophy and underdeveloped skeletal musculature. Head enlargement may be evident at birth or the head may become abnormally large in the early years of life. Additional clinical features include behavioral abnormalities, psychosis, learning difficulties, prognathism, myopia and astigmatism.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-TBC1D7 Recombinant Antibody (CBYJT-2056) (CAT#: CBMAB-T1152-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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