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Mouse Anti-TBC1D7 Recombinant Antibody (CBYJT-2055) (CBMAB-T1151-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TBC1D7 (TBC1 Domain Family Member 7). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all TBC1D7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-2055
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 1-16 at the N-terminus of TBC1D7 of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-16

Target

Full Name
TBC1D7 Gene(Protein Coding) TBC1 Domain Family Member 7
Introduction
TBC1D7 is a member of the TBC-domain containing protein family. TBC1D7 plays a role as a subunit of the tuberous sclerosis TSC1-TSC2 complex which plays a role in the regulation of cellular growth and differentiation. Mutations in TBC1D7 have been associated with autosomal recessive megalencephaly.
Entrez Gene ID
Human51256
Mouse67046
Rat361227
UniProt ID
HumanQ9P0N9
MouseQ9D0K0
RatD4AAY4
Alternative Names
TBC1 Domain Family Member 7; Cell Migration-Inducing Protein 23; TS Complex Subunit 3; TBC7; TBC1 Domain Family, Member 7; MGCPH; PIG51
Function
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Biological Process
Biological Process activation of GTPase activityIMP:UniProtKB1 Publication
Biological Process negative regulation of cilium assemblyIMP:UniProtKB1 Publication
Biological Process negative regulation of TOR signalingIDA:ComplexPortal1 Publication
Biological Process positive regulation of GTPase activityIDA:UniProtKB1 Publication
Biological Process positive regulation of protein ubiquitinationIDA:UniProtKB1 Publication
Biological Process response to growth factorIMP:UniProtKB1 Publication
Cellular Location
Cytoplasmic vesicle
Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.
Involvement in disease
Macrocephaly/megalencephaly syndrome, autosomal recessive (MGCPH):
An autosomal recessive disorder characterized by abnormal enlargement of the cerebral hemispheres, intellectual disability, large head, optic atrophy and underdeveloped skeletal musculature. Head enlargement may be evident at birth or the head may become abnormally large in the early years of life. Additional clinical features include behavioral abnormalities, psychosis, learning difficulties, prognathism, myopia and astigmatism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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