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Mouse Anti-TECTA Recombinant Antibody (CBYJT-2498) (CBMAB-T1647-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TECTA (Tectorin Alpha). The antibody can be used for immunoassay techniques, such as S-ELISA, ELISA, WB.
See all TECTA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2498
Antibody Isotype
IgG2a, κ
Application
S-ELISA, ELISA, WB

Basic Information

Immunogen
TECTA (NP_005413, 1981 a.a. ~ 2080 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1981-2080

Target

Full Name
tectorin alpha
Introduction
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in TECTA have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.
Entrez Gene ID
7007
UniProt ID
O75443
Alternative Names
Tectorin Alpha; Alpha-Tectorin; DFNA12; DFNB21; DFNA8
Function
One of the major non-collagenous components of the tectorial membrane (By similarity).
The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Biological Process
Biological Process cell-matrix adhesionIEA:InterPro
Biological Process sensory perception of soundTAS:ProtInc1 Publication
Cellular Location
Cell membrane
Secreted, extracellular space, extracellular matrix
Found in the non-collagenous matrix of the tectorial membrane.
Involvement in disease
Deafness, autosomal dominant, 12 (DFNA12):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Deafness, autosomal recessive, 21 (DFNB21):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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