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Mouse Anti-UGT1A6 Recombinant Antibody (C-12) (CBMAB-C4552-CN)

This product is a Mouse antibody that recognizes UGT1A6. The antibody C-12 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all UGT1A6 antibodies

Summary

Host Animal
Mouse
Specificity
human
Clone
C-12
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 81-176 mapping near the N-terminus of UGT1A6 of human origin
Specificity
human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
UDP glucuronosyltransferase 1 family, polypeptide A6
Introduction
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]
Entrez Gene ID
54578
UniProt ID
P19224
Alternative Names
UDP Glucuronosyltransferase Family 1 Member A6; UDP Glycosyltransferase 1 Family, Polypeptide A6; Phenol-Metabolizing UDP-Glucuronosyltransferase; UDP-Glucuronosyltransferase 1-F; UDP-Glucuronosyltransferase 1A6; EC 2.4.1.17; UDPGT 1-6; UGT1-06; UGT-1F; UGT1*6; UGT1.6;
Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
Biological Process
Biological Process cellular glucuronidation Source:UniProtKB1 Publication
Biological Process liver development Source:GO_Central1 Publication
Biological Process negative regulation of cellular glucuronidation Source:BHF-UCL
Biological Process negative regulation of fatty acid metabolic process Source:BHF-UCL
Biological Process negative regulation of glucuronosyltransferase activity Source:BHF-UCL
Biological Process xenobiotic metabolic process Source:UniProtKB1 Publication
Cellular Location
Microsome
Endoplasmic reticulum membrane
Topology
Helical: 490-506
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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