Mouse Anti-ZFHX3 Recombinant Antibody (3B1) (CBMAB-Z0200-WJ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity).
Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261).
Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845).
In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712).
Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).
Biological Process circadian regulation of gene expression Source:UniProtKB
Biological Process muscle organ development Source:UniProtKB-KW
Biological Process negative regulation of myoblast differentiation Source:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process positive regulation of cell adhesion Source:ARUK-UCL
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of myoblast differentiation Source:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase II Source:ARUK-UCL
Biological Process regulation of cell cycle Source:Ensembl
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of locomotor rhythm Source:UniProtKB
Biological Process regulation of neuron differentiation Source:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process response to transforming growth factor beta Source:UniProtKB1 Publication
Cytoplasm
Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.
Adult brain-derived ZFHX3 is sensitive, but embryonic brain-derived ZFHX3 is resistant to calpain 1-mediated proteolysis.
Ubiquitinated, leading to its proteasomal degradation.
Nuclear localization is essential for its sumoylation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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