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Mouse Anti-ZFHX3 Recombinant Antibody (3B1) (CBMAB-Z0200-WJ)

This product is a mouse antibody that recognizes ZFHX3. The antibody 3B1 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all ZFHX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B1
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
ZFHX3 (AA2811-2910) partial recombinant protein with GST tag. Immunogen sequence: EDFESPSMSS VNLNFDQTKL DNDDCSSVNT AITDTTTGDE GNADNDSATG IATETKSSSA PNEGLTKAAM MAMSEYEDRL SSGLVSPAPS FYSKEYDNEG
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
Zinc Finger Homeobox 3
Introduction
ZFHX3 (Zinc Finger Homeobox 3) is a Protein Coding gene. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. Diseases associated with ZFHX3 include Prostate Cancer and Atrial Fibrillation. Among its related pathways are Circadian rythm related genes and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ZFHX4.
Entrez Gene ID
463
UniProt ID
Q15911
Alternative Names
ATBT; ATBF1; ZNF927
Function
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025).
Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity).
Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261).
Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845).
In association with RUNX3, up-regulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712).
Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).
Biological Process
Biological Process brain development Source:GO_Central1 Publication
Biological Process circadian regulation of gene expression Source:UniProtKB
Biological Process muscle organ development Source:UniProtKB-KW
Biological Process negative regulation of myoblast differentiation Source:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process positive regulation of cell adhesion Source:ARUK-UCL
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of myoblast differentiation Source:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase II Source:ARUK-UCL
Biological Process regulation of cell cycle Source:Ensembl
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process regulation of locomotor rhythm Source:UniProtKB
Biological Process regulation of neuron differentiation Source:GO_Central1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process response to transforming growth factor beta Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm
Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.
PTM
Phosphorylation decreases its sensitivity to calpain-mediated proteolysis.
Adult brain-derived ZFHX3 is sensitive, but embryonic brain-derived ZFHX3 is resistant to calpain 1-mediated proteolysis.
Ubiquitinated, leading to its proteasomal degradation.
Nuclear localization is essential for its sumoylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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