Mouse Anti-ZFP36L1 Recombinant Antibody (1A3) (CBMAB-Z0222-WJ)

Mouse

Human

1A3

IgG1, κ

ELISA, RNAi, WB

ZFP36L1 (AA1-109) partial recombinant protein with GST tag.

Human

IgG1, κ

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

zinc finger protein 36, C3H type-like 1

ZFP36L1 (ZFP36 Ring Finger Protein Like 1) is a Protein Coding gene. Diseases associated with ZFP36L1 include Sotos Syndrome 1. Among its related pathways are Gene Expression and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is ZFP36L2.

BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173).
Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258).
Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868).
Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity).
Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173).
Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity).
Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863).
Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587).
Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173).
Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity).
May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217).
In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity).
Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity).
Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404).
In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157).
Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811).
Plays a role in vasculogenesis and endocardial development (By similarity).
Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009).
Plays a role in myoblast cell differentiation (By similarity).

Biological Process 3'-UTR-mediated mRNA destabilization Source:UniProtKB7 Publications
Biological Process apoptotic process Source:Ensembl
Biological Process cell population proliferation Source:Ensembl
Biological Process cellular response to cAMP Source:UniProtKB1 Publication
Biological Process cellular response to epidermal growth factor stimulus Source:UniProtKB1 Publication
Biological Process cellular response to fibroblast growth factor stimulus Source:UniProtKB
Biological Process cellular response to glucocorticoid stimulus Source:UniProtKB1 Publication
Biological Process cellular response to hypoxia Source:UniProtKB1 Publication
Biological Process cellular response to insulin stimulus Source:UniProtKB1 Publication
Biological Process cellular response to peptide hormone stimulus Source:UniProtKB2 Publications
Biological Process cellular response to raffinose Source:UniProtKB
Biological Process cellular response to salt stress Source:UniProtKB
Biological Process cellular response to transforming growth factor beta stimulus Source:UniProtKB1 Publication
Biological Process cellular response to tumor necrosis factor Source:UniProtKB1 Publication
Biological Process chorio-allantoic fusion Source:Ensembl
Biological Process ERK1 and ERK2 cascade Source:UniProtKB1 Publication
Biological Process heart development Source:Ensembl
Biological Process MAPK cascade Source:UniProtKB2 Publications
Biological Process mesendoderm development Source:UniProtKB
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process mRNA transport Source:UniProtKB1 Publication
Biological Process multicellular organism growth Source:Ensembl
Biological Process negative regulation of erythrocyte differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of mitotic cell cycle phase transition Source:UniProtKB
Biological Process neural tube development Source:Ensembl
Biological Process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:Ensembl
Biological Process nuclear-transcribed mRNA catabolic process, deadenylation-independent decay Source:UniProtKB
Biological Process p38MAPK cascade Source:UniProtKB
Biological Process phosphatidylinositol 3-kinase signaling Source:UniProtKB1 Publication
Biological Process positive regulation of fat cell differentiation Source:UniProtKB
Biological Process positive regulation of intracellular mRNA localization Source:UniProtKB1 Publication
Biological Process positive regulation of monocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source:UniProtKB
Biological Process proepicardium development Source:Ensembl
Biological Process protein kinase B signaling Source:UniProtKB
Biological Process regulation of B cell differentiation Source:UniProtKB
Biological Process regulation of gene expression Source:UniProtKB1 Publication
Biological Process regulation of keratinocyte apoptotic process Source:UniProtKB1 Publication
Biological Process regulation of keratinocyte differentiation Source:UniProtKB1 Publication
Biological Process regulation of keratinocyte proliferation Source:UniProtKB1 Publication
Biological Process regulation of mRNA 3'-end processing Source:UniProtKB1 Publication
Biological Process regulation of mRNA stability Source:UniProtKB8 Publications
Biological Process regulation of myoblast differentiation Source:UniProtKB
Biological Process regulation of stem cell proliferation Source:UniProtKB
Biological Process response to wounding Source:UniProtKB1 Publication
Biological Process spongiotrophoblast layer development Source:Ensembl
Biological Process T cell differentiation in thymus Source:UniProtKB
Biological Process vasculogenesis Source:Ensembl

Nucleus
Cytoplasm
Cytoplasmic granule
Cytoplasm, P-body
Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity).
Component of cytoplasmic stress granules (PubMed:15967811).
Localizes in processing bodies (PBs) (PubMed:17369404).

Phosphorylated (PubMed:19179481).
Phosphorylated by RPS6KA1 at Ser-334 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein receptor LDLR mRNA (PubMed:25106868).
Phosphorylated by protein kinase AKT1 at Ser-92 and Ser-203 in response to insulin; these phosphorylations stabilize ZFP36L1, increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization (PubMed:15538381, PubMed:17030608).
AKT1-mediated phosphorylation at Ser-92 does not impair ARE-containing RNA-binding (PubMed:15538381).
Phosphorylated at Ser-54, Ser-92 and Ser-203 by MAPKAPK2; these phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization in a protein kinase AKT1-independent manner (PubMed:18326031).
MAPKAPK2-mediated phosphorylations at Ser-54, Ser-92 and Ser-203 do not impair ARE-containing RNA-binding (PubMed:18326031).
Phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization during early adipogenesis in a p38 MAPK- and AKT-dependent manner (By similarity).
Ubiquitinated. Ubiquitination leads to proteasomal degradation, a process inhibited by phosphorylations at Ser-90, Ser-92 and Ser-203 (PubMed:17030608).