Mouse Anti-ZFPM2 Monoclonal Antibody (2D5) (CBMAB-0382-LY)

ZFPM2

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context.

FOG2; hFOG-2; ZC2HC11B; ZNF89B

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).

Biological Process cell differentiation Source:GO_Central1 Publication
Biological Process embryonic organ development Source:Ensembl
Biological Process gonadal mesoderm development Source:UniProtKB-KW
Biological Process heart development Source:GO_Central1 Publication
Biological Process in utero embryonic development Source:Ensembl
Biological Process lung development Source:Ensembl
Biological Process negative regulation of cell death Source:Ensembl
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of fat cell differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of female gonad development Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process outflow tract septum morphogenesis Source:BHF-UCL1 Publication
Biological Process positive regulation of cardiac muscle cell proliferation Source:BHF-UCL
Biological Process positive regulation of male gonad development Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process right ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication
Biological Process vasculogenesis Source:Ensembl
Biological Process ventricular septum morphogenesis Source:BHF-UCL1 Publication

Nucleus

Tetralogy of Fallot (TOF):
A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
Diaphragmatic hernia 3 (DIH3):
Form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.
46,XY sex reversal 9 (SRXY9):
A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females or have ambiguous external genitalia.
Conotruncal heart malformations (CTHM):
A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle.

Sumoylation reduces transcriptional repression activity.