CEP57 Matched Antibody Pair (261) (APMAB-261LY)

Name: CEP57 Matched Antibody Pair (261)
SKU: APMAB-261LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-CEP57 monoclonal antibody, 100 ug

Detection Antibody

Anti-CEP57 Rabbit polyclonal antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Alternative Names

Centrosomal Protein 57; Testis-Specific Protein 57; Centrosomal Protein 57kDa; FGF2-Interacting Protein; Translokin; TSP57; Proliferation-Inducing Protein 8;

Entrez Gene ID

9702

UniProt ID

Q86XR8

More Infomation

Ito, K. K., Watanabe, K., Ishida, H., Matsuhashi, K., Chinen, T., Hata, S., & Kitagawa, D. (2021). Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle. Journal of Cell Biology, 220(3).

Ito, K. K., Watanabe, K., Ishida, H., Matsuhashi, K., Chinen, T., Hata, S., & Kitagawa, D. (2020). Cep57 and Cep57L1 cooperatively maintain centriole engagement during interphase to ensure proper centriole duplication cycle. bioRxiv.

Zhao, H., Yang, S., Duan, X., Chen, Q., Li, G., Huang, Q., ... & Yan, X. (2019). Cep57 and Cep57l1 cooperate to recruit the Cep63-Cep152 complex for centriole biogenesis. bioRxiv, 842682.

Watanabe, K., Takao, D., Ito, K. K., Takahashi, M., & Kitagawa, D. (2019). The Cep57-pericentrin module organizes PCM expansion and centriole engagement. Nature communications, 10(1), 1-13.

De la Torre-García, O., Mar-Aldama, R., Salgado-Sangri, R., Diaz-Gomez, N., Bonilla-Arcaute, L., Diaz-Ponce-Medrano, J., ... & Martínez-Hernández, A. (2019). A homozygous CEP57 c. 915_925dupCAATGTTCAGC mutation in a patient with mosaic variegated aneuploidy syndrome with rhizomelic shortening in the upper and lower limbs and a narrow thorax. European journal of medical genetics, 62(3), 195-197.

Aziz, K., Sieben, C. J., Jeganathan, K. B., Hamada, M., Davies, B. A., Velasco, R. O. F., ... & van Deursen, J. M. (2018). Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression. The Journal of clinical investigation, 128(8), 3517-3534.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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