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IKBKE Matched Antibody Pair (612) (APMAB-612LY)

This antibody pair set can be used for detecting and quantifying protein level of human IKBKE.
See all IKBKE antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-IKBKE monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-IKBKE Biotinylated mouse monoclonal, IgG2b antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]
Alternative Names
Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon
Entrez Gene ID
9641
UniProt ID
Q14164

Xie, W., Jiang, Q., Wu, X., Wang, L., Gao, B., Sun, Z., ... & Guo, J. (2022). IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis. Cell Death & Differentiation, 29(8), 1528-1540.

Zhu, T., Hong, J., Shuai, Z., Xu, S., Qian, D., Hong, X., ... & Liu, L. (2020). The decreased expression of IKBKE in systemic lupus erythematosus. Clinical Rheumatology, 39, 2611-2617.

Qiao, J., Chen, Y., Mi, Y., Jin, H., Wang, L., Huang, T., ... & Zou, Z. (2020). Macrophages confer resistance to BET inhibition in triple-negative breast cancer by upregulating IKBKE. Biochemical Pharmacology, 180, 114126.

Bainbridge, A., Walker, S., Smith, J., Patterson, K., Dutt, A., Ng, Y. M., ... & Coffey, K. (2020). IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway. Nucleic Acids Research, 48(10), 5366-5382.

Yin, M., Wang, X., & Lu, J. (2020). Advances in IKBKE as a potential target for cancer therapy. Cancer medicine, 9(1), 247-258.

Zhao, Z., Li, Y., Liu, H., Jain, A., Patel, P. V., & Cheng, K. (2020). Co-delivery of IKBKE siRNA and cabazitaxel by hybrid nanocomplex inhibits invasiveness and growth of triple-negative breast cancer. Science advances, 6(29), eabb0616.

Guo, G., Sun, Y., Hong, R., Xiong, J., Lu, Y., Liu, Y., ... & Huang, Q. (2020). IKBKE enhances TMZ-chemoresistance through upregulation of MGMT expression in glioblastoma. Clinical and Translational Oncology, 22, 1252-1262.

Zhang, Z., Wang, Z., Huang, K., Liu, Y., Wei, C., Zhou, J., ... & Han, L. (2019). PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma. Cancer Letters, 443, 91-107.

Leonardi, M., Perna, E., Tronnolone, S., Colecchia, D., & Chiariello, M. (2019). Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy. Autophagy, 15(2), 312-326.

Liu, S., Marneth, A. E., Alexe, G., Walker, S. R., Gandler, H. I., Ye, D. Q., ... & Frank, D. A. (2018). The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy. Blood advances, 2(23), 3428-3442.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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