AATK

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. [provided by RefSeq]

apoptosis-associated tyrosine kinase

May be involved in neuronal differentiation.

Brain development
Peptidyl-tyrosine autophosphorylation
Protein phosphorylation

Cytoplasm; Membrane; Perinuclear region. Predominantly perinuclear.

Autophosphorylated. Phosphorylated by CDK5.