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ASNS

The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. There are three alternatively spliced transcript variants encoding the same protein described for this gene. [provided by RefSeq]
Full Name
asparagine synthetase
Biological Process
Asparagine biosynthetic process Source: MGI
Aspartate family amino acid metabolic process Source: Reactome
Cellular response to glucose starvation Source: UniProtKB
Cellular response to hormone stimulus Source: Ensembl
Glutamine metabolic process Source: UniProtKB-KW
L-asparagine biosynthetic process Source: UniProtKB-UniPathway
Liver development Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of mitotic cell cycle Source: UniProtKB
Response to amino acid Source: Ensembl
Response to follicle-stimulating hormone Source: Ensembl
Response to light stimulus Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to methotrexate Source: Ensembl
Response to toxic substance Source: Ensembl
Cellular Location
Cytosol
Involvement in disease
Asparagine synthetase deficiency (ASNSD): An inborn error of asparagine biosynthesis that results in a severe neurologic disorder characterized by microcephaly, severely delayed psychomotor development, progressive encephalopathy, cortical atrophy, and seizure or hyperekplexic activity.

Anti-ASNS antibodies

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Target: ASNS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B3
Application*: E
Target: ASNS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B3
Application*: E, IP
Target: ASNS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1B2
Application*: WB
Target: ASNS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 1A10
Application*: IF, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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