ATOH1
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq]
Full Name
ATOH1
Function
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).
Biological Process
Auditory receptor cell fate determination Source: Ensembl
Auditory receptor cell fate specification Source: Ensembl
Axon guidance Source: Ensembl
Central nervous system development Source: ProtInc
Cerebral cortex development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Neuron differentiation Source: GO_Central
Neuron migration Source: Ensembl
Notch signaling pathway Source: Ensembl
Positive regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Auditory receptor cell fate specification Source: Ensembl
Axon guidance Source: Ensembl
Central nervous system development Source: ProtInc
Cerebral cortex development Source: Ensembl
Inner ear morphogenesis Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Neuron differentiation Source: GO_Central
Neuron migration Source: Ensembl
Notch signaling pathway Source: Ensembl
Positive regulation of inner ear auditory receptor cell differentiation Source: Ensembl
Positive regulation of neuron differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
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Anti-ATOH1 antibodies
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Target: ATOH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 18A6
Application*: IP, WB
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E2
Application*: WB, E
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B1
Application*: WB, E
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1C5
Application*: WB, E, IF
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYM-0871
Application*: E, IC, IF, WB
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A12
Application*: E, IF, WB
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F3
Application*: E, WB
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A8
Application*: E, WB
Target: ATOH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0315
Application*: WB
Target: ATOH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B12
Application*: WB, E, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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