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CAST

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Full Name
Calpastatin
Function
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Biological Process
Inhibition of cysteine-type endopeptidase activity Source: CAFA
Negative regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
Presynaptic active zone organization Source: ARUK-UCL
Cellular Location
Cytosol; Endoplasmic reticulum; Cytoplasm; Membrane
Involvement in disease
Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK): An autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma.
PTM
The N-terminus is blocked.

Anti-CAST antibodies

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Target: CAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Cattle, Human, Pig, Sheep
Clone: 1F7E3D10
Application*: WB, P, IC
Target: CAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 2C5
Application*: E, IF, WB
Target: CAST
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Human, Mouse, Dog, Pig, Rat, Sheep, Rabbit
Clone: 2G11D6
Application*: IC/IF, IH, C, P, WB
Target: CAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q31
Application*: E, IC, C, WB
Target: CAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E7
Application*: F, IH, P, WB
Target: CAST
Host: Mouse
Specificity: Human
Clone: CBFYH-0039
Application*: E, WB
Target: CAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Pig, Cattle
Clone: CBXC-2685
Application*: WB, IH, IF, P
Target: CAST
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Pig, Cattle, Dog, Fish, Rabbit
Clone: CBXC-2762
Application*: WB, IH, P, C, IC
Target: CAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1989
Application*: WB, IH, F
Target: CAST
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Dog, Human, Pig, Rabbit, Rat
Clone: CBLNC-136
Application*: IC, IH-F, WB
Target: CAST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP82
Application*: P, F
Target: CAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0866
Application*: WB, F, IH, P
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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