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CAST

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Full Name
Calpastatin
Function
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Biological Process
Inhibition of cysteine-type endopeptidase activity Source: CAFA
Negative regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
Presynaptic active zone organization Source: ARUK-UCL
Cellular Location
Cytosol; Endoplasmic reticulum; Cytoplasm; Membrane
Involvement in disease
Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK): An autosomal recessive disease characterized by generalized, continuous shedding of the outer layers of the epidermis, leukonychia, acral punctate keratosis, cheilitis, knuckle pads with multiple hyperkeratotic micropapules involving the interphalangeal joints, and palmoplantar keratoderma.
PTM
The N-terminus is blocked.
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Anti-CAST antibodies

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Rabbit Anti-CAST Recombinant Antibody (SP82) (CBMAB-1319-CN)

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Target: CAST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP82
Application*: WB, IH, F, IF
Datasheet SDS

Mouse Anti-CAST Recombinant Antibody (CBLNC-136) (CBMAB-1318-CN)

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Target: CAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLNC-136
Application*: E, P, IF, IP, WB
Datasheet SDS

CAST Matched Antibody Pair (185) (APMAB-185LY)

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Target: CAST
Specificity: Human
Datasheet SDS

Mouse Anti-CAST Recombinant Antibody (CBXC-2685) (CBMAB-C4632-CQ)

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Target: CAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2685
Application*: E, IH
Datasheet SDS

Mouse Anti-CAST Recombinant Antibody (CBFYC-0866) (CBMAB-C0921-FY)

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Target: CAST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0866
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-CAST Recombinant Antibody (2Q31) (CBMAB-C5365-LY)

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Target: CAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 2Q31
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-CAST Recombinant Antibody (2C5) (CBMAB-C4792-LY)

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Target: CAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 2C5
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-CAST Recombinant Antibody (CBFYH-0039) (CBMAB-H0852-FY)

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Target: CAST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0039
Application*: P, IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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