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CD40LG

CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and CD40 receptor binding.
Full Name
CD40 Ligand
Function
Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973).
Costimulates T-cell proliferation and cytokine production (PubMed:8617933).
Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933).
Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973).
Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037).
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity).
Involved in immunoglobulin class switching (By similarity).
CD40 ligand, soluble form: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Biological Process
Activation of JUN kinase activity Source: UniProtKB
B cell differentiation Source: Ensembl
B cell proliferation Source: UniProtKB
CD40 signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Isotype switching Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Platelet activation Source: UniProtKB
Positive regulation of endothelial cell apoptotic process Source: BHF-UCL
Positive regulation of interleukin-10 production Source: UniProtKB
Positive regulation of interleukin-12 production Source: UniProtKB
Positive regulation of interleukin-4 production Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of T cell proliferation Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of immunoglobulin production Source: Ensembl
T cell costimulation Source: UniProtKB
Tumor necrosis factor-mediated signaling pathway Source: Reactome
Cellular Location
Cell membrane; Cell surface
CD40 ligand, soluble form: Secreted. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Involvement in disease
Immunodeficiency with hyper-IgM, type 1 (HIGM1): Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
Topology
Cytoplasmic: 1-22
Helical: 23-46
Extracellular: 47-261
PTM
The soluble form derives from the membrane form by proteolytic processing.
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
Not O-glycosylated.

Anti-CD40LG antibodies

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Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0177
Application*: F, FN, IA, IP, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MK13A4
Application*: E
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0221
Application*: IC, WB
Target: CD40LG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-0220
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: R1/69
Application*: IH
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: TRAP1.3.6
Application*: F, MC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: LL48
Application*: IF, FN, N
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-0219
Application*: SE, E, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1811
Application*: F
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1588
Application*: F, IP
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-1108
Application*: WB, P
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: A060
Application*: FC, IHC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP408
Application*: ICC, IHC, IP, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: D4
Application*: ICC, IHC, IP, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB102
Application*: IF, FC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB101
Application*: IF, FC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB100
Application*: IF, FC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb270
Application*: FC, FuncS, Immuno assays, IP, WB
Target: CD40LG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5J9Y
Application*: WB, IP, P
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0173-14B9
Application*: WB, IH, P
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: MAB0820
Application*: B, F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TRAP-1
Application*: F
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: AP-MAB0712
Application*: F
Target: CD40LG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: YMF323.6.2
Application*: FC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J39
Application*: E, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1896
Application*: FC
Target: CD40LG
Host: Mouse
Specificity: Human
Clone: 3G3
Application*: E, WB
Target: CD40LG
Host: Human
Specificity: Human
Clone: Ruplizumab
Application*: FC, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: B-B29
Application*: IH, FC
Target: CD40LG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 323.6.2
Application*: F, WB
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: MR1
Application*: F, IH
Target: CD40LG
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0763
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2266
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1176
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster
Clone: LL2
Application*: F, IF
Target: CD40LG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: hu5c8 (Ruplizumab)
Application*: WB, F, N, MC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2343
Application*: WB, SE
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1429
Application*: E
Target: CD40LG
Host: Mouse
Specificity: Human
Clone: CBYY-C1428
Application*: E, WB
Target: CD40LG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: CBYY-C1427
Application*: F
Target: CD40LG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-1303
Application*: E
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1302
Application*: E, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYC-1301
Application*: P, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYC-1300
Application*: F, IH, N, WB
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-1299
Application*: F, IH
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0157
Application*: WB, E
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0712
Application*: C, F
Target: CD40LG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: 3H1902
Application*: F
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 39H5
Application*: F, IP
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: 24-31
Application*: F
Target: CD40LG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 208109
Application*: F, N, MC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0728
Application*: WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0693
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0595
Application*: E, F, IH, IP, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0358
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0266
Application*: IF, F
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBYY-C0158
Application*: F, IH, IP
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0157
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8J12
Application*: E
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H113
Application*: E, C, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E2
Application*: E, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A3
Application*: E, WB
Target: CD40LG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 202
Application*: E
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L164
Application*: F, IH, N, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14B9
Application*: P, WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11J26
Application*: WB
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 40804
Application*: WB, F, IH, MC
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1894
Application*: F
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 30B4
Application*: E
Target: CD40LG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B10
Application*: E, WB
Target: CD40LG
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: MR-1
Application*: B
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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