CD40LG Matched Antibody Pair (223) (APMAB-223LY)

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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-CD40LG polyclonal antibody, 100 ug
Detection Antibody
Anti-CD40LG Mouse monoclonal, IgG2b antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and CD40 receptor binding.
Alternative Names
CD40 Ligand; TNF-Related Activation Protein; Tumor Necrosis Factor (Ligand) Superfamily Member 5; T-B Cell-Activating Molecule; CD40 Antigen Ligand; T-Cell Antigen Gp39; TNFSF5; CD40-L; CD40L; TRAP; Tumor Necrosis Factor (Ligand) Superfamily, Member 5 (Hyper-IgM Syndrome);
Entrez Gene ID
959
UniProt ID
P29965
More Infomation

Fadul, C. E., Mao-Draayer, Y., Ryan, K. A., Noelle, R. J., Wishart, H. A., Channon, J. Y., ... & Kasper, L. H. (2021). Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis. Neurology-Neuroimmunology Neuroinflammation, 8(6).

França, T. T., Barreiros, L. A., Al-Ramadi, B. K., Ochs, H. D., Cabral-Marques, O., & Condino-Neto, A. (2019). CD40 ligand deficiency: treatment strategies and novel therapeutic perspectives. Expert review of clinical immunology, 15(5), 529-540.

Ferrua, F., Galimberti, S., Courteille, V., Slatter, M. A., Booth, C., Moshous, D., ... & SCETIDE, P. (2019). Hematopoietic stem cell transplantation for CD40 ligand deficiency: results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study. Journal of Allergy and Clinical Immunology, 143(6), 2238-2253.

Du, X., Tang, W., Chen, X., Zeng, T., Wang, Y., Chen, Z., ... & Zhao, X. (2019). Clinical, genetic and immunological characteristics of 40 Chinese patients with CD40 ligand deficiency. Scandinavian journal of immunology, 90(4), e12798.

Saliba, D. G., Céspedes-Donoso, P. F., Bálint, Š., Compeer, E. B., Korobchevskaya, K., Valvo, S., ... & Dustin, M. L. (2019). Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells. Elife, 8, e47528.

Cabral-Marques, O., França, T. T., Al-Sbiei, A., Schimke, L. F., Khan, T. A., Feriotti, C., ... & Condino-Neto, A. (2018). CD40 ligand deficiency causes functional defects of peripheral neutrophils that are improved by exogenous IFN-γ. Journal of Allergy and Clinical Immunology, 142(5), 1571-1588.

Komlósi, Z. I., Kovács, N., van de Veen, W., Kirsch, A. I., Fahrner, H. B., Wawrzyniak, M., ... & Akdis, C. A. (2018). Human CD40 ligand–expressing type 3 innate lymphoid cells induce IL-10–producing immature transitional regulatory B cells. Journal of Allergy and Clinical Immunology, 142(1), 178-194.

França, T. T., Leite, L. F., Maximo, T. A., Lambert, C. G., Zurro, N. B., Forte, W. C., & Condino-Neto, A. (2018). A novel de novo mutation in the CD40 ligand gene in a patient with a mild X-linked hyper-IgM phenotype initially diagnosed as CVID: new aspects of old diseases. Frontiers in pediatrics, 6, 130.

Han, W., Jackson, D. A., Matissek, S. J., Misurelli, J. A., Neil, M. S., Sklavanitis, B., ... & Elsawa, S. F. (2017). Novel molecular mechanism of regulation of CD40 ligand by the transcription factor GLI2. The Journal of Immunology, 198(11), 4481-4489.

Cabral-Marques, O., Ramos, R. N., Schimke, L. F., Khan, T. A., Amaral, E. P., Bomfim, C. C. B., ... & Condino-Neto, A. (2017). Human CD40 ligand deficiency dysregulates the macrophage transcriptome causing functional defects that are improved by exogenous IFN-γ. Journal of Allergy and Clinical Immunology, 139(3), 900-912.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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Alternative Versions

CD40LG Matched Antibody Pair (224) (CAT#: APMAB-224LY)

CD40LG Matched Antibody Pair (225) (CAT#: APMAB-225LY)

CD40LG Matched Antibody Pair (226) (CAT#: APMAB-226LY)

CD40LG Matched Antibody Pair (227) (CAT#: APMAB-227LY)

CD40LG Matched Antibody Pair (228) (CAT#: APMAB-228LY)

Antibody Pairs

CD40LG Matched Antibody Pair (224) (CAT#: APMAB-224LY)

CD40LG Matched Antibody Pair (225) (CAT#: APMAB-225LY)

CD40LG Matched Antibody Pair (226) (CAT#: APMAB-226LY)

CD40LG Matched Antibody Pair (227) (CAT#: APMAB-227LY)

CD40LG Matched Antibody Pair (228) (CAT#: APMAB-228LY)

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CD40LG Matched Antibody Pair (227) (CAT#: APMAB-227LY)

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CD40LG Matched Antibody Pair (225) (CAT#: APMAB-225LY)

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Isotype control

For research use only. Not intended for any clinical use.

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