CDH13

CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include Lung Cancer and Cervical Cancer. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is CDH2.

Full Name

Cadherin 13

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Biological Process

Adherens junction organization Source: Reactome
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Endothelial cell migration Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Keratinocyte proliferation Source: BHF-UCL
Lamellipodium assembly Source: BHF-UCL
Localization within membrane Source: BHF-UCL
Low-density lipoprotein particle mediated signaling Source: BHF-UCL
Mitotic cell cycle Source: Ensembl
Negative regulation of cell adhesion Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Positive regulation of calcium-mediated signaling Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Rac protein signal transduction Source: BHF-UCL
Regulation of endocytosis Source: BHF-UCL
Regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Rho protein signal transduction Source: BHF-UCL
Sprouting angiogenesis Source: BHF-UCL

Cellular Location

Cell membrane