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Rat Anti-CDH13 (AA 23-692) Recombinant Antibody (CBFYH-0066) (CBMAB-H0888-FY)

This product is rat antibody that recognizes CDH13. The antibody CBFYH-0066 can be used for immunoassay techniques such as: FC, IHC-Fr, WB.
See all CDH13 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
CBFYH-0066
Antibody Isotype
IgG2a
Application
FC, IHC-Fr, WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Cadherin-13 Glu23-Ala692
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 5% trehalose
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 23-692

Target

Full Name
Cadherin 13
Introduction
CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include Lung Cancer and Cervical Cancer. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is CDH2.
Entrez Gene ID
Human1012
Mouse12554
UniProt ID
HumanP55290
MouseQ9WTR5
Alternative Names
Cadherin 13; T-Cadherin; H-Cadherin (Heart); Heart Cadherin; T-Cad; CDHH
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
Biological Process
Adherens junction organization Source: Reactome
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Endothelial cell migration Source: BHF-UCL
Homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
Keratinocyte proliferation Source: BHF-UCL
Lamellipodium assembly Source: BHF-UCL
Localization within membrane Source: BHF-UCL
Low-density lipoprotein particle mediated signaling Source: BHF-UCL
Mitotic cell cycle Source: Ensembl
Negative regulation of cell adhesion Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Positive regulation of calcium-mediated signaling Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of positive chemotaxis Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Rac protein signal transduction Source: BHF-UCL
Regulation of endocytosis Source: BHF-UCL
Regulation of epidermal growth factor receptor signaling pathway Source: BHF-UCL
Rho protein signal transduction Source: BHF-UCL
Sprouting angiogenesis Source: BHF-UCL
Cellular Location
Cell membrane

Mossink, B., Van Rhijn, J. R., Wang, S., Linda, K., Vitale, M. R., Zöller, J. E., ... & Kasri, N. N. (2021). Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks. Molecular Psychiatry, 1-18.

Shiu, B. H., Lu, W. Y., Tantoh, D. M., Chou, M. C., Nfor, O. N., Huang, C. C., & Liaw, Y. P. (2021). Interactive association between dietary fat and sex on CDH13 cg02263260 methylation. BMC Medical Genomics, 14(1), 1-9.

Xu, D., Yuan, H., Meng, Z., Yang, C., Li, Z., Li, M., ... & Tu, H. (2020). Cadherin 13 inhibits pancreatic cancer progression and epithelial-mesenchymal transition by Wnt/β-catenin signaling. Journal of Cancer, 11(8), 2101.

Yang, Y. R., Kabir, M. H., Park, J. H., Park, J. I., Kang, J. S., Ju, S., ... & Kwon, K. S. (2020). Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss. Aging (Albany NY), 12(9), 8652.

Forero, A., Ku, H. P., Malpartida, A. B., Wäldchen, S., Alhama-Riba, J., Kulka, C., ... & Lesch, K. P. (2020). Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Neuropharmacology, 168, 108018.

Kiser, D. P., Popp, S., Schmitt-Boehrer, A. G., Strekalova, T., van den Hove, D. L., Lesch, K. P., & Rivero, O. (2019). Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 89, 158-168.

Tantra, M., Guo, L., Kim, J., Zainolabidin, N., Eulenburg, V., Augustine, G. J., & Chen, A. I. (2018). Conditional deletion of Cadherin 13 perturbs Golgi cells and disrupts social and cognitive behaviors. Genes, Brain and Behavior, 17(6), e12466.

Killen, A. C., Barber, M., Paulin, J. J., Ranscht, B., Parnavelas, J. G., & Andrews, W. D. (2017). Protective role of Cadherin 13 in interneuron development. Brain Structure and Function, 222(8), 3567-3585.

Forero, A., Rivero, O., Wäldchen, S., Ku, H. P., Kiser, D. P., Gärtner, Y., ... & Lesch, K. P. (2017). Cadherin-13 deficiency increases dorsal raphe 5-HT neuron density and prefrontal cortex innervation in the mouse brain. Frontiers in cellular neuroscience, 11, 307.

Vargas-Alarcon, G., Martinez-Rodriguez, N., Velazquez-Cruz, R., Perez-Mendez, O., Posadas-Sanchez, R., Posadas-Romero, C., ... & Fragoso, J. M. (2017). The T> A (rs11646213) gene polymorphism of cadherin-13 (CDH13) gene is associated with decreased risk of developing hypertension in Mexican population. Immunobiology, 222(10), 973-978.

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For research use only. Not intended for any clinical use.

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