CFLAR

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Full Name

CASP8 And FADD Like Apoptosis Regulator

Function

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Apoptotic process Source: UniProtKB
Cellular response to dexamethasone stimulus Source: Ensembl
Cellular response to epidermal growth factor stimulus Source: Ensembl
Cellular response to estradiol stimulus Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to insulin stimulus Source: Ensembl
Cellular response to nitric oxide Source: Ensembl
Negative regulation of apoptotic process Source: ProtInc
Negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
Negative regulation of cellular response to transforming growth factor beta stimulus Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
Negative regulation of hepatocyte apoptotic process Source: Ensembl
Negative regulation of myoblast fusion Source: BHF-UCL
Negative regulation of reactive oxygen species biosynthetic process Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of extracellular matrix organization Source: Ensembl
Positive regulation of glomerular mesangial cell proliferation Source: Ensembl
Positive regulation of hepatocyte proliferation Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of neuron projection development Source: Ensembl
Positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
Regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
Regulation of necroptotic process Source: UniProtKB
Regulation of skeletal muscle satellite cell proliferation Source: BHF-UCL
Regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
Response to testosterone Source: Ensembl
Skeletal muscle atrophy Source: BHF-UCL
Skeletal muscle tissue development Source: BHF-UCL
Skeletal muscle tissue regeneration Source: BHF-UCL
Skeletal myofibril assembly Source: BHF-UCL
Viral process Source: UniProtKB-KW
Wound healing Source: BHF-UCL

Cellular Location

Cytosol; Ripoptosome; CD95 death-inducing signaling complex; Death-inducing signaling complex; Cytoplasm; Membrane raft

PTM

Proteolytically processed by CASP8 generating subunit p43 and p12.