CLDN7

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Full Name

Claudin 7

Function

Plays a major role in tight junction-specific obliteration of the intercellular space.

Biological Process

Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell adhesion Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Positive regulation of cell motility Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Response to ethanol Source: Ensembl

Cellular Location

Cell membrane; Basolateral cell membrane; Tight junction. Co-localizes with EPCAM at the basolateral cell membrane and tight junction.

Topology

Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-117
Helical: 118-138
Extracellular: 139-160
Helical: 161-181
Cytoplasmic: 182-221

PTM

Phosphorylated.