CSPG5

CSPG5 (Chondroitin Sulfate Proteoglycan 5) is a Protein Coding gene. Diseases associated with CSPG5 include Spontaneous Ocular Nystagmus and Kabuki Syndrome 1. Among its related pathways are Glycosaminoglycan metabolism and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include growth factor activity.

Full Name

Chondroitin Sulfate Proteoglycan 5

Function

May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.

Biological Process

Cell projection morphogenesis Source: GO_Central
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Cytoskeleton organization Source: UniProtKB
Dermatan sulfate biosynthetic process Source: Reactome
Glial cell projection elongation Source: UniProtKB
Intracellular transport Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Regulation of synaptic vesicle exocytosis Source: Ensembl
Trans-synaptic signaling, modulating synaptic transmission Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane; Cell membrane; Synaptic cell membrane; Golgi apparatus membrane; Cell surface. In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts.

Topology

Extracellular: 31-423
Helical: 424-444
Cytoplasmic: 445-566

PTM

N-glycosylated.
O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation (By similarity).
Phosphorylated; in intracellular and extracellular parts.