CUL2

CUL2 (Cullin 2) is a Protein Coding gene. Diseases associated with CUL2 include Hypoxia and Von Hippel-Lindau Syndrome. Among its related pathways are Innate Immune System and ErbB signaling pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and protein complex binding. An important paralog of this gene is CUL1.

Full Name

cullin 2

Function

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346).

May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Biological Process

G1/S transition of mitotic cell cycle Source: ProtInc
Intrinsic apoptotic signaling pathway Source: ProtInc
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
Viral process Source: UniProtKB-KW

Cellular Location

Cytosol; Nucleoplasm; Cul2-RING ubiquitin ligase complex; Cullin-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; VCB complex

PTM

Neddylated; which enhances the ubiquitination activity of ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes. CBC(VHL) complex formation seems to promote neddylation. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity).