ELK1

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
Full Name
ELK1, ETS Transcription Factor
Research Area
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
Biological Process
Cell differentiation Source: GO_Central
Cellular response to gamma radiation Source: Ensembl
Cellular response to testosterone stimulus Source: Ensembl
Gene expression Source: Ensembl
Liver development Source: Ensembl
Lung development Source: Ensembl
Positive regulation of neuron death Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to fibroblast growth factor Source: UniProtKB
Response to light stimulus Source: Ensembl
Cellular Location
Nucleus
PTM
Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).
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Anti-ELK1 antibodies

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Mouse Anti-ELK1 Recombinant Antibody (8) (CBMAB-AO385LY)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 8
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (30) (CBMAB-P0305-YC)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 30
Application*: E, WB
Datasheet SDS

Rabbit Anti-ELK1 Recombinant Antibody (EG1087) (V2LY-0825-LY85)

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Target: ELK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1087
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (AO384) (V2LY-0825-LY83)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: AO384
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (CBFYE-0780) (V2LY-0825-LY81)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-0780
Application*: E, IP
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (E0240) (V2LY-0825-LY80)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: E0240
Application*: WB, IF
Datasheet SDS

Mouse Anti-ELK1 (Phospho-Ser383) Recombinant Antibody (1133) (V2LY-0825-LY79)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 1133
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (CBT472) (V2LY-0625-LY3500)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT472
Application*: WB, P, IF, E
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (CBT473) (V2LY-0625-LY3499)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT473
Application*: WB, E
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (CBT4085) (V2LY-0625-LY2133)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4085
Application*: IH
Datasheet SDS

Mouse Anti-ELK1 Recombinant Antibody (CBT2234) (V2LY-0625-LY2132)

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Target: ELK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2234
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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