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F8

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
Full Name
Coagulation Factor VIII
Research Area
Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
Biological Process
Acute-phase response Source: UniProtKB-KW
Blood coagulation Source: ProtInc
Blood coagulation, intrinsic pathway Source: GO_Central
Cellular Location
Extracellular space
Involvement in disease
Hemophilia A (HEMA):
The disease is caused by variants affecting the gene represented in this entry. Of particular interest for the understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but the protein is non-functional; i.e. the F8 activity is much less than the plasma protein level. CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein. A disorder of blood coagulation characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe forms are characterized by bleeding after trauma or surgery.
PTM
Sulfation on Tyr-1699 is essential for binding vWF.

Anti-F8 antibodies

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Mouse Anti-F8 Recombinant Antibody (CAP1031) (CBMAB-AP2172LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CAP1031
Application*: FA, IF, WB

Recombinant Mouse Anti-F8 Antibody (CB2978) (CBMAB-MD1179-LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB2978
Application*: E, WB

Recombinant Mouse Anti-F8 Antibody (104) (CBMAB-MD1178-LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 104
Application*: E

Mouse Anti-F8 Recombinant Antibody (IHC571) (CBMAB-MA087-YC)

Datasheet SDS
Target: F8
Host: Mouse
Specificity: Human
Clone: IHC571
Application*: IH

Mouse Anti-F8 Recombinant Antibody (1E8) (CBMAB-A2782-LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E8
Application*: SE, E

Mouse Anti-F8 Recombinant Antibody (RFFVIIIC/8) (CBMAB-C11534-LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: RFFVIIIC/8
Application*: E, R, WB

Mouse Anti-F8 Recombinant Antibody (RFFVIIIC/5) (CBMAB-C3442-CN)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RFFVIIIC/5
Application*: E, WB

Mouse Anti-F8 Recombinant Antibody (CBWJC-3640) (CBMAB-C4884WJ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3640
Application*: P

Recombinant Mouse Anti-F8 Recombinant Antibody (c/8) (CBMAB-XB0442-YC)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: c/8
Application*: IF, FN, WB

Recombinant Mouse Anti-F8 Recombinant Antibody (c/10) (CBMAB-XB0441-YC)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: c/10
Application*: IF, WB

Rabbit Anti-F8 Recombinant Antibody (CBYY-C2452) (CBMAB-C3892-YY)

Datasheet SDS
Target: F8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2452
Application*: E

Mouse Anti-F8 Recombinant Antibody (CBYY-C2451) (CBMAB-C3891-YY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2451
Application*: WB

Rabbit Anti-F8 Recombinant Antibody (CBFYC-2641) (CBMAB-C2715-FY)

Datasheet SDS
Target: F8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2641
Application*: E

Mouse Anti-F8 Recombinant Antibody (CBFYC-2640) (CBMAB-C2714-FY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2640
Application*: E

Mouse Anti-F8 Recombinant Antibody (CBFYC-2639) (CBMAB-C2713-FY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2639
Application*: E, WB

Mouse Anti-F8 Recombinant Antibody (5E9B2) (CBMAB-C7526-LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E9B2
Application*: WB

Rabbit Anti-F8 Recombinant Antibody (226) (CBMAB-C4422-LY)

Datasheet SDS
Target: F8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 226
Application*: E

Mouse Anti-F8 Recombinant Antibody (104) (CBMAB-C2059-LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 104
Application*: E, FN, WB

Mouse Anti-F8 Recombinant Antibody (012) (CBMAB-C1613-LY)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 012
Application*: E, WB

Mouse Anti-F8 Recombinant Antibody (CBXF-2772) (CBMAB-F3489-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2772
Application*: E, N, WB

Mouse Anti-F8 Recombinant Antibody (CBXF-0195) (CBMAB-F3125-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0195
Application*: P

Mouse Anti-F8 Recombinant Antibody (CBXF-0188) (CBMAB-F2962-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0188
Application*: IH

Mouse Anti-F8 Recombinant Antibody (GMA-012) (CBMAB-F2630-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GMA-012
Application*: WB, E, P

Mouse Anti-F8 Recombinant Antibody (CBXF-2220) (CBMAB-F2606-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2220
Application*: E, WB

Mouse Anti-F8 Recombinant Antibody (CBXF-3549) (CBMAB-F2090-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXF-3549
Application*: E

Mouse Anti-F8 Recombinant Antibody (CBXF-2382) (CBMAB-F1890-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2382
Application*: E, WB

Rat Anti-F8 Recombinant Antibody (CBXF-2491) (CBMAB-F1881-CQ)

Datasheet SDS
Target: F8
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-2491
Application*: E, WB

Mouse Anti-F8 Recombinant Antibody (G99) (CBMAB-F1840-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: G99
Application*: E, BL

Mouse Anti-F8 Recombinant Antibody (CBXF-3354) (CBMAB-F1839-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Pig
Clone: CBXF-3354
Application*: E, BL

Mouse Anti-F8 Recombinant Antibody (CBXF-3353) (CBMAB-F1838-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3353
Application*: E, IP, LI

Mouse Anti-F8 Recombinant Antibody (CBXF-3352) (CBMAB-F1837-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXF-3352
Application*: E, BL

Mouse Anti-F8 Recombinant Antibody (CBXF-3351) (CBMAB-F1834-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Pig
Clone: CBXF-3351
Application*: E, LI, BL

Mouse Anti-F8 Recombinant Antibody (2G10) (CBMAB-F1833-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2G10
Application*: E, LI, BL

Mouse Anti-F8 Recombinant Antibody (CBXF-3760) (CBMAB-F1832-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3760
Application*: E, WB

Rat Anti-F8 Recombinant Antibody (CBXF-0194) (CBMAB-F1822-CQ)

Datasheet SDS
Target: F8
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-0194
Application*: E, WB, LI

Rat Anti-F8 Recombinant Antibody (CBXF-0199) (CBMAB-F1821-CQ)

Datasheet SDS
Target: F8
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXF-0199
Application*: E, WB

Mouse Anti-F8 Recombinant Antibody (CBXF-3349) (CBMAB-F1805-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: CBXF-3349
Application*: E, LI, BL

Mouse Anti-F8 Recombinant Antibody (1D4) (CBMAB-F1804-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D4
Application*: E, LI, IH, F, BL

Mouse Anti-F8 Recombinant Antibody (CBXF-1389) (CBMAB-F1659-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1389
Application*: IA

Mouse Anti-F8 Recombinant Antibody (MH104) (CBMAB-F1571-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: MH104
Application*: E, IH, WB

Mouse Anti-F8 Recombinant Antibody (CBXF-0200) (CBMAB-F1425-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0200
Application*: WB, IC, P, C, E

Mouse Anti-F8 Recombinant Antibody (CBXF-1916) (CBMAB-F1085-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1916
Application*: WB, E, P

Mouse Anti-F8 Recombinant Antibody (CBXF-1915) (CBMAB-F1084-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1915
Application*: WB, E, IF

Rat Anti-F8 Recombinant Antibody (CBXF-0196) (CBMAB-F0772-CQ)

Datasheet SDS
Target: F8
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-0196
Application*: WB, E

Mouse Anti-F8 Recombinant Antibody (CBXF-2773) (CBMAB-F0593-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: CBXF-2773
Application*: E, R, WB

Mouse Anti-F8 Recombinant Antibody (F8 2.2.9) (CBMAB-F0547-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: F8 2.2.9
Application*: P, E, WB

Mouse Anti-F8 Recombinant Antibody (CBXF-0190) (CBMAB-F0316-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0190
Application*: E

Mouse Anti-F8 Recombinant Antibody (CBXF-2200) (CBMAB-F0241-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2200
Application*: E, WB

Mouse Anti-F8 Recombinant Antibody (RFF-VIII:c/8) (CBMAB-F0037-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: RFF-VIII:c/8
Application*: WB, IF, FN

Mouse Anti-F8 Recombinant Antibody (RFF-VIII:c/10) (CBMAB-F0035-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: RFF-VIII:c/10
Application*: WB, IF

Mouse Anti-F8 Recombinant Antibody (2A5) (CBMAB-F0034-CQ)

Datasheet SDS
Target: F8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A5
Application*: E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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