FZD5

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.

Full Name

frizzled class receptor 5

Function

Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549).

Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity).

In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549).

Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).

A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).

Biological Process

Angiogenesis Source: Ensembl
Anterior/posterior axis specification, embryo Source: BHF-UCL
Apoptotic process involved in morphogenesis Source: Ensembl
Branching involved in labyrinthine layer morphogenesis Source: Ensembl
Canonical Wnt signaling pathway Source: BHF-UCL
Cell maturation Source: Ensembl
Cellular response to molecule of bacterial origin Source: BHF-UCL
Chorionic trophoblast cell differentiation Source: Ensembl
Embryonic axis specification Source: BHF-UCL
Embryonic camera-type eye morphogenesis Source: Ensembl
Labyrinthine layer blood vessel development Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Neuron differentiation Source: UniProtKB
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of interleukin-1 beta production Source: ARUK-UCL
Positive regulation of JUN kinase activity Source: Ensembl
Positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Positive regulation of T cell cytokine production Source: CACAO
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Post-embryonic camera-type eye development Source: Ensembl
Regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Regulation of bicellular tight junction assembly Source: Ensembl
Regulation of chorionic trophoblast cell proliferation Source: Ensembl
Spemann organizer formation Source: BHF-UCL
Synapse assembly Source: ParkinsonsUK-UCL
Syncytiotrophoblast cell differentiation involved in labyrinthine layer development Source: Ensembl
T cell differentiation in thymus Source: Ensembl

Cellular Location

Golgi apparatus membrane; Cell membrane; Synapse; Perikaryon; Dendrite; Axon. Localized at the plasma membrane and also found at the Golgi.

Topology

Extracellular: 27-238
Helical: 239-259
Cytoplasmic: 260-270
Helical: 271-291
Extracellular: 292-315
Helical: 316-336
Cytoplasmic: 337-358
Helical: 359-379
Extracellular: 380-402
Helical: 403-423
Cytoplasmic: 424-449
Helical: 450-470
Extracellular: 471-500
Helical: 501-521
Cytoplasmic: 522-585

PTM

Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.