GP6

Part of these sequences was used to elongate GP5 and GP6 at their 3′ ends to generate the primers GP5+ and GP6+, respectively.
Full Name
Glycoprotein Vi Platelet
Function
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Biological Process
Collagen-activated signaling pathway Source: ARUK-UCL
Enzyme linked receptor protein signaling pathway Source: ProtInc
Platelet activation Source: UniProtKB
Positive regulation of platelet aggregation Source: ARUK-UCL
Cellular Location
Isoform 1&2: Cell membrane
Involvement in disease
Bleeding disorder, platelet-type, 11 (BDPLT11):
A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.
Topology
Extracellular: 21-267
Helical: 268-288
Cytoplasmic: 289-339
PTM
N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
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Anti-GP6 antibodies

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Mouse Anti-GP6 Recombinant Antibody (CBLG1-1570) (CBMAB-G4463-LY)

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Target: GP6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1570
Application*: WB
Datasheet SDS

Mouse Anti-GP6 Recombinant Antibody (HY101) (CBMAB-G0656-LY)

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Target: GP6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: HY101
Application*: F
Datasheet SDS

Rat Anti-GP6 Recombinant Antibody (784808) (CBMAB-G0655-LY)

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Target: GP6
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 784808
Application*: F
Datasheet SDS

Rat Anti-GP6 Recombinant Antibody (2F11-C3) (CBMAB-G0654-LY)

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Target: GP6
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 2F11-C3
Application*: F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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