GP6

Part of these sequences was used to elongate GP5 and GP6 at their 3′ ends to generate the primers GP5+ and GP6+, respectively.

Glycoprotein Vi Platelet

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

Collagen-activated signaling pathway Source: ARUK-UCL
Enzyme linked receptor protein signaling pathway Source: ProtInc
Platelet activation Source: UniProtKB
Positive regulation of platelet aggregation Source: ARUK-UCL

Isoform 1&2: Cell membrane

Bleeding disorder, platelet-type, 11 (BDPLT11):
A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.

Extracellular: 21-267
Helical: 268-288
Cytoplasmic: 289-339

N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).