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Rat Anti-GP6 Recombinant Antibody (784808) (CBMAB-G0655-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rat
Clone
784808
Application
FC
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse GPVI, Gly24-Lys265, Accession # P0C191
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Buffer
Trehalose
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Glycoprotein Vi Platelet
Entrez Gene ID
243816
UniProt ID
P0C191
Alternative Names
9830166G18Rik; Gm469; Gpvi
Function
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Biological Process
Collagen-activated signaling pathway Source: ARUK-UCL
Enzyme linked receptor protein signaling pathway Source: ProtInc
Platelet activation Source: UniProtKB
Positive regulation of platelet aggregation Source: ARUK-UCL
Cellular Location
Isoform 1&2: Cell membrane
Involvement in disease
Bleeding disorder, platelet-type, 11 (BDPLT11):
A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.
Topology
Extracellular: 21-267
Helical: 268-288
Cytoplasmic: 289-339
PTM
N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).

Dalby, A., Mezzano, D., Rivera, J., Watson, S. P., & Morgan, N. V. (2022). Introduction of an ancient founder glycoprotein VI mutation into the Chilean population. Blood Advances, 6(22), 5866-5869.

Zhi, Z., Jooss, N. J., Sun, Y., Colicchia, M., Slater, A., Moran, L. A., ... & Iqbal, A. J. (2022). Galectin‐9 activates platelet ITAM receptors glycoprotein VI and C‐type lectin‐like receptor‐2. Journal of Thrombosis and Haemostasis, 20(4), 936-950.

Perrella, G., Nagy, M., Watson, S. P., & Heemskerk, J. W. (2021). Platelet GPVI (glycoprotein VI) and thrombotic complications in the venous system. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(11), 2681-2692.

Skille, H., Paulsen, B., Hveem, K., Gabrielsen, M. E., Brumpton, B., Hindberg, K., ... & Hansen, J. B. (2020). Genetic variation of platelet glycoprotein VI and the risk of venous thromboembolism. haematologica, 105(7), e358.

An, H. J., Ahn, E. H., Kim, J. O., Ryu, C. S., Park, H. S., Cho, S. H., ... & Kim, N. K. (2020). Association between Platelet-Specific Collagen Receptor Glycoprotein 6 Gene Variants, Selected Biomarkers, and Recurrent Pregnancy Loss in Korean Women. Genes, 11(8), 862.

Nurden, A. T. (2019). Clinical significance of altered collagen-receptor functioning in platelets with emphasis on glycoprotein VI. Blood Reviews, 38, 100592.

Mueller, S. K., Nocera, A. L., Dillon, S. T., Gu, X., Wendler, O., Otu, H. H., ... & Bleier, B. S. (2019, February). Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin‐5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps. In International Forum of Allergy & Rhinology (Vol. 9, No. 2, pp. 177-186).

Jandrot-Perrus, M., Hermans, C., & Mezzano, D. (2019). Platelet glycoprotein VI genetic quantitative and qualitative defects. Platelets, 30(6), 708-713.

Mangin, P. H., Onselaer, M. B., Receveur, N., Le Lay, N., Hardy, A. T., Wilson, C., ... & Watson, S. P. (2018). Immobilized fibrinogen activates human platelets through glycoprotein VI. haematologica, 103(5), 898.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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