GPR52

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM, Jul 2002]

Full Name

G Protein-Coupled Receptor 52

Function

Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241).

May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241).

Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).

Biological Process

Cellular response to light stimulus Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Locomotory behavior Source: UniProtKB
Phototransduction Source: GO_Central
Response to drug Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-44
Helical: 45-65
Cytoplasmic: 66-87
Helical: 88-108
Extracellular: 109-116
Helical: 117-137
Cytoplasmic: 138-159
Helical: 160-180
Extracellular: 181-203
Helical: 204-224
Cytoplasmic: 225-265
Helical: 266-286
Extracellular: 287-296
Helical: 297-317
Cytoplasmic: 318-361