GPRC5B

This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Full Name

G Protein-Coupled Receptor Class C Group 5 Member B

Function

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Biological Process

Positive regulation of canonical Wnt signaling pathway Source: CAFA
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: CAFA
Positive regulation of inflammatory response Source: CAFA
Positive regulation of macrophage cytokine production Source: CAFA
Positive regulation of neuron differentiation Source: CAFA
Positive regulation of protein tyrosine kinase activity Source: CAFA

Cellular Location

Cell membrane; Cytoplasmic vesicle membrane. Localized in the plasma membrane and perinuclear vesicles.

Topology

Extracellular: 29-56
Helical: 57-77
Cytoplasmic: 78-94
Helical: 95-115
Extracellular: 116-126
Helical: 127-147
Cytoplasmic: 148-162
Helical: 163-183
Extracellular: 184-199
Helical: 200-220
Cytoplasmic: 221-234
Helical: 235-255
Extracellular: 256-271
Helical: 272-292
Cytoplasmic: 293-403

Anti-GPRC5B antibodies

Mouse Anti-GPRC5B Recombinant Antibody (1H1) (CBMAB-G4687-LY)

Datasheet

SDS

Target: GPRC5B

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1H1

Application*: FC, CyTOF-ready

Rabbit Anti-GPRC5B Recombinant Antibody (EG1413) (CBMAB-EN1692-LY)

Datasheet

SDS

Target: GPRC5B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1413

Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000

Mouse Anti-GPRC5B Recombinant Antibody (CBFYH-0463) (CBMAB-H1335-FY)

Datasheet

SDS

Target: GPRC5B

Host: Mouse

Specificity: Human

Clone: CBFYH-0463

Application*: WB, IP, E

Rabbit Anti-GPRC5B Recombinant Antibody (BA0082) (CBMAB-0353CQ)

Datasheet

SDS

Target: GPRC5B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: BA0082

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)