GRM5

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.

glutamate metabotropic receptor 5

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

Calcium-mediated signaling using intracellular calcium source Source: ARUK-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Chemical synaptic transmission Source: ProtInc
Cognition Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Learning Source: Ensembl
Learning or memory Source: ARUK-UCL
Locomotory behavior Source: Ensembl
Modulation of age-related behavioral decline Source: ARUK-UCL
Phospholipase C-activating G protein-coupled glutamate receptor signaling pathway Source: ProtInc
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Postsynaptic modulation of chemical synaptic transmission Source: Ensembl
Regulation of intracellular calcium activated chloride channel activity Source: ARUK-UCL
Regulation of long-term neuronal synaptic plasticity Source: Ensembl
Regulation of protein phosphorylation Source: ARUK-UCL
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Regulation of translation Source: ARUK-UCL
Regulation of translational elongation Source: ARUK-UCL
Synapse organization Source: ARUK-UCL
Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Source: GO_Central

Cell membrane

Extracellular: 22-580
Helical: 581-603
Cytoplasmic: 604-613
Helical: 614-636
Extracellular: 637-644
Helical: 645-667
Cytoplasmic: 668-693
Helical: 694-714
Extracellular: 715-737
Helical: 738-759
Cytoplasmic: 760-772
Helical: 773-795
Extracellular: 796-798
Helical: 799-820
Cytoplasmic: 821-1212