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Recombinant Rabbit Anti-GRM5 Antibody (CBAb114) (CBMAB-Ab114-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
CBAb114
Application
WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200
Immunogen
Recombinant protein of human GRM5
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
glutamate metabotropic receptor 5
Introduction
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human2915
Mouse108071
Rat24418
UniProt ID
HumanP41594
MouseQ3UVX5
RatP31424
Alternative Names
GRM5; GPRC1E; MGLUR5; PPP1R86; mGlu5; metabotropic glutamate receptor 5
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Biological Process
Calcium-mediated signaling using intracellular calcium source Source: ARUK-UCL
Cellular response to amyloid-beta Source: ARUK-UCL
Chemical synaptic transmission Source: ProtInc
Cognition Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Learning Source: Ensembl
Learning or memory Source: ARUK-UCL
Locomotory behavior Source: Ensembl
Modulation of age-related behavioral decline Source: ARUK-UCL
Phospholipase C-activating G protein-coupled glutamate receptor signaling pathway Source: ProtInc
Positive regulation of protein tyrosine kinase activity Source: ARUK-UCL
Postsynaptic modulation of chemical synaptic transmission Source: Ensembl
Regulation of intracellular calcium activated chloride channel activity Source: ARUK-UCL
Regulation of long-term neuronal synaptic plasticity Source: Ensembl
Regulation of protein phosphorylation Source: ARUK-UCL
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Regulation of translation Source: ARUK-UCL
Regulation of translational elongation Source: ARUK-UCL
Synapse organization Source: ARUK-UCL
Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 22-580
Helical: 581-603
Cytoplasmic: 604-613
Helical: 614-636
Extracellular: 637-644
Helical: 645-667
Cytoplasmic: 668-693
Helical: 694-714
Extracellular: 715-737
Helical: 738-759
Cytoplasmic: 760-772
Helical: 773-795
Extracellular: 796-798
Helical: 799-820
Cytoplasmic: 821-1212

Holmes, S. E., Asch, R. H., Davis, M. T., DellaGioia, N., Pashankar, N., Gallezot, J. D., ... & Esterlis, I. (2022). Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorder. Biological Psychiatry.

Abd-Elrahman, K. S., & Ferguson, S. S. (2022). Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer's disease. Annual Review of Pharmacology and Toxicology, 62, 235-254.

Moreno García, C. A., Zhou, H., Altimira, D., Dynes, R., Gregorini, P., Jayathunga, S., ... & Hickford, J. (2022). The glutamate metabotropic receptor 5 (GRM5) gene is associated with beef cattle home range and movement tortuosity. Journal of Animal Science and Biotechnology, 13(1), 1-16.

Choi, W. M., Ryu, T., Lee, J. H., Shim, Y. R., Kim, M. H., Kim, H. H., ... & Jeong, W. I. (2021). Metabotropic glutamate receptor 5 in natural killer cells attenuates liver fibrosis by exerting cytotoxicity to activated stellate cells. Hepatology, 74(4), 2170-2185.

Ibrahim, K. S., Abd-Elrahman, K. S., El Mestikawy, S., & Ferguson, S. S. (2020). Targeting vesicular glutamate transporter machinery: implications on metabotropic glutamate receptor 5 signaling and behavior. Molecular pharmacology, 98(4), 314-327.

Esterlis, I., Holmes, S. E., Sharma, P., Krystal, J. H., & DeLorenzo, C. (2018). Metabotropic glutamatergic receptor 5 and stress disorders: knowledge gained from receptor imaging studies. Biological psychiatry, 84(2), 95-105.

Akkus, F., Mihov, Y., Treyer, V., Ametamey, S. M., Johayem, A., Senn, S., ... & Hasler, G. (2018). Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder. Translational psychiatry, 8(1), 17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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