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HDAC6

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Full Name
HDAC6
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385).

Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10220385).

Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10220385).

In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065).

Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141).

Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532).

In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173).

Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173).
Biological Process
Aggresome assembly Source: BHF-UCL
Autophagy Source: UniProtKB-KW
Axonal transport of mitochondrion Source: ARUK-UCL
Cellular response to hydrogen peroxide Source: BHF-UCL
Cellular response to misfolded protein Source: Ensembl
Cellular response to topologically incorrect protein Source: BHF-UCL
Cilium assembly Source: Reactome
Collateral sprouting Source: Ensembl
Dendritic spine morphogenesis Source: Ensembl
Histone deacetylation Source: BHF-UCL
Hsp90 deacetylation Source: Ensembl
Intracellular protein transport Source: BHF-UCL
Lysosome localization Source: BHF-UCL
Negative regulation of hydrogen peroxide metabolic process Source: BHF-UCL
Negative regulation of microtubule depolymerization Source: Ensembl
Negative regulation of oxidoreductase activity Source: BHF-UCL
Negative regulation of protein-containing complex assembly Source: ARUK-UCL
Negative regulation of protein-containing complex disassembly Source: BHF-UCL
Negative regulation of proteolysis Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
Peptidyl-lysine deacetylation Source: BHF-UCL
Polyubiquitinated misfolded protein transport Source: BHF-UCL
Positive regulation of epithelial cell migration Source: BHF-UCL
Positive regulation of hydrogen peroxide-mediated programmed cell death Source: BHF-UCL
Positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
Positive regulation of signaling receptor activity Source: BHF-UCL
Protein-containing complex disassembly Source: Ensembl
Protein deacetylation Source: UniProtKB
Protein destabilization Source: Ensembl
Protein polyubiquitination Source: Ensembl
Protein quality control for misfolded or incompletely synthesized proteins Source: BHF-UCL
Regulation of androgen receptor signaling pathway Source: BHF-UCL
Regulation of autophagy Source: ParkinsonsUK-UCL
Regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Regulation of establishment of protein localization Source: Ensembl
Regulation of fat cell differentiation Source: Ensembl
Regulation of gene expression, epigenetic Source: UniProtKB
Regulation of macroautophagy Source: BHF-UCL
Regulation of microtubule-based movement Source: BHF-UCL
Regulation of protein stability Source: ParkinsonsUK-UCL
Response to growth factor Source: BHF-UCL
Response to misfolded protein Source: BHF-UCL
Tubulin deacetylation Source: UniProtKB
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; Cytoskeleton; Perikaryon; Dendrite; Axon. It is mainly cytoplasmic, where it is associated with microtubules.
Involvement in disease
Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM):
A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation.
PTM
Phosphorylated by AURKA.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.

Anti-HDAC6 antibodies

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Target: HDAC6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A4
Application*: IP, M
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0884
Application*: E, IF, WB
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0883
Application*: E, WB
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYH-0881
Application*: F, IF, IH, WB
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYH-0880
Application*: WB, IF, F, IH
Target: HDAC6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D2E5
Application*: WB, IP, P, IF
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4G6F9
Application*: E, WB, F
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 18E2SC
Application*: WB
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0879
Application*: E, WB
Target: HDAC6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D21B10
Application*: WB, IP
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A6
Application*: WB, E
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E2
Application*: WB, E
Target: HDAC6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B2-F5-G6
Application*: WB
Target: HDAC6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-061
Application*: E, WB, IH, IP
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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