IPPK
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export.
Full Name
inositol-pentakisphosphate 2-kinase
Function
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
Biological Process
Inositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Inositol phosphate metabolic processTAS:Reactome
Inositol phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription of nucleolar large rRNA by RNA polymerase IManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Cytoplasm; Nucleus
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