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KLB

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Full Name
Klotho Beta
Function
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Biological Process
Carbohydrate metabolic processIEA:InterPro
Fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Location
Cell membrane
Topology
Extracellular: 1-996
Helical: 997-1017
Cytoplasmic: 1018-1044

Anti-KLB antibodies

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Mouse Anti-KLB Recombinant Antibody (A768) (CBMAB-AP4158LY)

Datasheet Datasheet SDS SDS
Target: KLB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: A768
Application*: ICC, IHC, IP, WB

Mouse Anti-KLB Recombinant Antibody (885935) (CBMAB-K1024-LY)

Datasheet Datasheet SDS SDS
Target: KLB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 885935
Application*: WB

Rabbit Anti-KLB Recombinant Antibody (1025C) (CBMAB-K0131-LY)

Datasheet Datasheet SDS SDS
Target: KLB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1025C
Application*: F, IC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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