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KLB

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).

Full Name

Klotho Beta

Function

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).

Biological Process

Carbohydrate metabolic processIEA:InterPro
Fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Cellular Location

Cell membrane

Topology

Extracellular: 1-996
Helical: 997-1017
Cytoplasmic: 1018-1044

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Anti-KLB antibodies

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Mouse Anti-KLB Recombinant Antibody (885935) (CBMAB-K1024-LY)

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Target: KLB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 885935

Application*: WB

Rabbit Anti-KLB Recombinant Antibody (1025C) (CBMAB-K0131-LY)

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Target: KLB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 1025C

Application*: F, IC

Mouse Anti-KLB Recombinant Antibody (A768) (CBMAB-AP4158LY)

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Target: KLB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: A768

Application*: ICC, IHC, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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