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Rabbit Anti-KLB Recombinant Antibody (1025C) (CBMAB-K0131-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
1025C
Application
FC, ICC
Immunogen
Mouse myeloma cell line, NS0-derived recombinant human Klotho beta with a C-terminal 10 His tag. Phe53-Leu997
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA
Preservative
Sodium Azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Klotho Beta
Introduction
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Entrez Gene ID
152831
UniProt ID
Q86Z14
Alternative Names
Klotho Beta; Klotho Beta-Like Protein; BetaKlotho; B-Klotho; BKL; Klotho Beta Like; Beta-Klotho; EC 3.2.1;
Function
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Biological Process
Carbohydrate metabolic processIEA:InterPro
Fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Location
Cell membrane
Topology
Extracellular: 1-996
Helical: 997-1017
Cytoplasmic: 1018-1044

Aaldijk, A. S., Verzijl, C. R., Jonker, J. W., & Struik, D. (2023). Biological and pharmacological functions of the FGF19-and FGF21-coreceptor beta klotho. Frontiers in endocrinology, 14, 1150222.

Bono, B. S., Koziel Ly, N. K., Miller, P. A., Williams‐Ikhenoba, J., Dumiaty, Y., & Chee, M. J. (2022). Spatial distribution of beta‐klotho mRNA in the mouse hypothalamus, hippocampal region, subiculum, and amygdala. Journal of Comparative Neurology, 530(10), 1634-1657.

Guo, Z., Wang, Y., Wen, X., Xu, X., & Yan, L. (2022). β-Klotho Promotes the Development of Intrauterine Adhesions via the PI3K/AKT Signaling Pathway. International Journal of Molecular Sciences, 23(19), 11294.

Hou, Z., Ding, Q., Li, Y., Zhao, Z., Yan, F., Li, Y., ... & Zhao, L. (2022). Intestinal epithelial β klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury. EBioMedicine, 82.

Moure, R., Cairó, M., Morón-Ros, S., Quesada-López, T., Campderrós, L., Cereijo, R., ... & Giralt, M. (2021). Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21. American Journal of Physiology-Endocrinology and Metabolism, 320(4), E822-E834.

Zhou, J., Ben, S., Xu, T., Xu, L., & Yao, X. (2021). Serum β-klotho is a potential biomarker in the prediction of clinical outcomes among patients with NSCLC. Journal of Thoracic Disease, 13(5), 3137.

Dongiovanni, P., Crudele, A., Panera, N., Romito, I., Meroni, M., De Stefanis, C., ... & Alisi, A. (2020). β-Klotho gene variation is associated with liver damage in children with NAFLD. Journal of Hepatology, 72(3), 411-419.

Lin, Z. Z., Hsu, C., Jeng, Y. M., Hu, F. C., Pan, H. W., Wu, Y. M., ... & Cheng, A. L. (2019). Klotho‐beta and fibroblast growth factor 19 expression correlates with early recurrence of resectable hepatocellular carcinoma. Liver International, 39(9), 1682-1691.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-KLB Recombinant Antibody (885935) (CAT#: CBMAB-K1024-LY)

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For research use only. Not intended for any clinical use.

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