LIPH

LIPH is a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.

Full Name

LIPH

Function

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Biological Process

Fatty acid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Lipid catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidic acid biosynthetic processTAS:Reactome
Triglyceride catabolic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted
Cell membrane

Involvement in disease

Hypotrichosis 7 (HYPT7):
A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. HYPT7 inheritance is autosomal recessive.
Woolly hair autosomal recessive 2 (ARWH2):
A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis.