MAGEA4

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
MAGE Family Member A4
Function
Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486).
Also negatively regulates p53-mediated apoptosis (PubMed:22842486).
Biological Process
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
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Anti-MAGEA4 antibodies

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Mouse Anti-MAGEA4 Antibody (8BA19) (CBMAB-1406CQ)

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Target: MAGEA4
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 8BA19
Application*: E, P, IH, M, WB
Datasheet SDS

Mouse Anti-MAGEA4 Recombinant Antibody (3D12) (CBMAB-A5160-LY)

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Target: MAGEA4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D12
Application*: WB, E
Datasheet SDS

Mouse Anti-MAGEA4 Recombinant Antibody (CBFYM-1312) (CBMAB-M1471-FY)

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Target: MAGEA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1312
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-MAGEA4 Recombinant Antibody (CBFYM-1311) (CBMAB-M1470-FY)

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Target: MAGEA4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1311
Application*: WB
Datasheet SDS

Mouse Anti-MAGEA4 Antibody (8BA20) (CBMAB-1407CQ)

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Target: MAGEA4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8BA20
Application*: E, P, IH, M
Datasheet SDS

Mouse Anti-MAGEA4 Recombinant Antibody (CBT3266) (V2LY-0625-LY1800)

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Target: MAGEA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3266
Application*: WB, F
Datasheet SDS

Mouse Anti-MAGEA4 Recombinant Antibody (CBT2391) (V2LY-0625-LY1799)

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Target: MAGEA4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2391
Application*: WB, IH, F
Datasheet SDS

MAGEA4 Matched Antibody Pair (704) (APMAB-704LY)

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Target: MAGEA4
Specificity: Human
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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