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MAT2B

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms.

Full Name

MAT2B

Function

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345).

Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).

Biological Process

One-carbon metabolic process Source: UniProtKB-KW
S-adenosylmethionine biosynthetic process Source: UniProtKB

Cellular Location

Cytosol
Extracellular region or secreted
extracellular exosome
Nucleus
Other locations
methionine adenosyltransferase complex

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Anti-MAT2B antibodies

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Mouse Anti-MAT2B Recombinant Antibody (CBFYM-1758) (CBMAB-M1926-FY)

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Target: MAT2B

Host: Mouse

Specificity: Human

Clone: CBFYM-1758

Application*: WB, IP, IF, P, E

Mouse Anti-MAT2B Antibody (1G7) (CBMAB-0634-YC)

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Target: MAT2B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1G7

Application*: IP, M

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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