MAT2B

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms.

Full Name

MAT2B

Function

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345).

Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).

Biological Process

One-carbon metabolic process Source: UniProtKB-KW
S-adenosylmethionine biosynthetic process Source: UniProtKB

Cellular Location

Cytosol
Extracellular region or secreted
extracellular exosome
Nucleus
Other locations
methionine adenosyltransferase complex

Anti-MAT2B antibodies

Mouse Anti-MAT2B Antibody (1G7) (CBMAB-0634-YC)

Datasheet

SDS

Target: MAT2B

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1G7

Application*: IP, M

Mouse Anti-MAT2B Recombinant Antibody (CBFYM-1758) (CBMAB-M1926-FY)

Datasheet

SDS

Target: MAT2B

Host: Mouse

Specificity: Human

Clone: CBFYM-1758

Application*: WB, IP, IF, P, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)