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Mouse Anti-MAT2B Recombinant Antibody (CBFYM-1758) (CBMAB-M1926-FY)

This product is mouse antibody that recognizes MAT2B. The antibody CBFYM-1758 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all MAT2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1758
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAT2B
Introduction
The protein encoded by this gene belongs to the methionine adenosyltransferase family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
27430
UniProt ID
Q9NZL9
Alternative Names
Methionine Adenosyltransferase 2B; Short Chain Dehydrogenase/Reductase Family 23E, Member 1; Putative DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase; Methionine Adenosyltransferase II, Beta; MAT II Beta; TGR; Beta Regulatory Subunit Of Methionine Adenosyltransferase; Methionine Adenosyltransferase 2 Subunit Beta; DTDP-4-Keto-6-Deoxy-D-Glucose 4-Reductase
Function
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345).

Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).
Biological Process
One-carbon metabolic process Source: UniProtKB-KW
S-adenosylmethionine biosynthetic process Source: UniProtKB
Cellular Location
Cytosol
Extracellular region or secreted
extracellular exosome
Nucleus
Other locations
methionine adenosyltransferase complex

Wang, D., Zhu, X., Siqin, B., Ren, C., & Yi, F. (2022). Long non-coding RNA CYTOR modulates cancer progression through miR-136-5p/MAT2B axis in renal cell carcinoma. Toxicology and applied pharmacology, 447, 116067.

Bailey, J., Douglas, H., Masino, L., de Carvalho, L. P. S., & Argyrou, A. (2021). Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B. Biochemistry, 60(47), 3621-3632.

Liu, J., Liu, H., Zeng, Q., Xu, P., Liu, M., & Yang, N. (2020). Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1α axis. Cancer cell international, 20, 1-12.

Zhao, J. P., & Chen, L. L. (2020). Circular RNA MAT2B induces colorectal cancer proliferation via sponging miR-610, resulting in an increased E2F1 expression. Cancer Management and Research, 7107-7116.

Li, Q., Pan, X., Zhu, D., Deng, Z., Jiang, R., & Wang, X. (2019). Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma through the miR‐338‐3p/PKM2 axis under hypoxic stress. Hepatology, 70(4), 1298-1316.

Wu, L., Chen, P., Ying, J., Zhang, Q., Liu, F., Lv, B., ... & Liu, J. (2019). MAT2B mediates invasion and metastasis by regulating EGFR signaling pathway in hepatocellular carcinoma. Clinical and Experimental Medicine, 19, 535-546.

Li, C., Fei, K., Tian, F., Gao, C., & Song, Y. (2019). Adipose-derived mesenchymal stem cells attenuate ischemic brain injuries in rats by modulating miR-21-3p/MAT2B signaling transduction. Croatian medical journal, 60(5), 439-448.

Xu, J., Wu, D., Wang, S., & Wang, Z. (2019). MAT2B expression correlates with poor prognosis in triple-negative breast cancer. Cancer Management and Research, 5501-5511.

Simile, M. M., Peitta, G., Tomasi, M. L., Brozzetti, S., Feo, C. F., Porcu, A., ... & Pascale, R. M. (2019). MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes. Oncotarget, 10(29), 2835.

Ge, X., Li, W., Huang, S., Yin, Z., Yang, M., Han, Z., ... & Zhang, J. (2019). Increased miR-21-3p in injured brain microvascular endothelial cells after traumatic brain injury aggravates blood–brain barrier damage by promoting cellular apoptosis and inflammation through targeting MAT2B. Journal of neurotrauma, 36(8), 1291-1305.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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