MED1

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

mediator complex subunit 1

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119).

Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Androgen biosynthetic process Source: UniProtKB
Angiogenesis Source: UniProtKB
Animal organ regeneration Source: Ensembl
Brain development Source: Ensembl
Cell morphogenesis Source: UniProtKB
Cellular response to epidermal growth factor stimulus Source: UniProtKB
Cellular response to hepatocyte growth factor stimulus Source: Ensembl
Cellular response to steroid hormone stimulus Source: UniProtKB
Cellular response to thyroid hormone stimulus Source: UniProtKB
Embryonic heart tube development Source: Ensembl
Embryonic hemopoiesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Embryonic placenta development Source: Ensembl
Enucleate erythrocyte development Source: Ensembl
Epithelial cell proliferation involved in mammary gland duct elongation Source: Ensembl
Erythrocyte development Source: UniProtKB
Fat cell differentiation Source: MGI
Intracellular steroid hormone receptor signaling pathway Source: UniProtKB
Keratinocyte differentiation Source: UniProtKB
Lactation Source: Ensembl
Lens development in camera-type eye Source: UniProtKB
Liver development Source: Ensembl
Mammary gland branching involved in pregnancy Source: Ensembl
Mammary gland branching involved in thelarche Source: Ensembl
Megakaryocyte development Source: UniProtKB
Monocyte differentiation Source: Ensembl
mRNA transcription by RNA polymerase II Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of keratinocyte proliferation Source: UniProtKB
Negative regulation of neuron differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Peroxisome proliferator activated receptor signaling pathway Source: Ensembl
Positive regulation of erythrocyte differentiation Source: UniProtKB
Positive regulation of G0 to G1 transition Source: Ensembl
Positive regulation of gene expression Source: UniProtKB
Positive regulation of hepatocyte proliferation Source: Ensembl
Positive regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
Positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
Positive regulation of keratinocyte differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: UniProtKB
Protein import into nucleus Source: Ensembl
Regulation of RNA biosynthetic process Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of vitamin D receptor signaling pathway Source: Ensembl
Retinal pigment epithelium development Source: Ensembl
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Thyroid hormone generation Source: Ensembl
Thyroid hormone mediated signaling pathway Source: UniProtKB
Ventricular trabecula myocardium morphogenesis Source: Ensembl

Nucleus
Note: A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.

Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus (PubMed:16314496). Phosphorylation increases its interaction with PSIP1 (PubMed:29997176).